The limited proliferative capacity of erythroid precursors complicates the production of red blood cells for clinical purposes in vitro. Here, the authors show that erythroid proliferative capacity can be vastly increased by BMI1 overexpression, which regulates erythroid self-renewal through both gene repression and activation.
- Kathleen E. McGrath
- Jayme L. Olsen
- James Palis
