EZHIP, an inhibitor of PRC2, is required for female fertility in mice. Here, the authors show that maternal deletion of Ezhip impairs H3K27me3 deposition post-fertilization. This notably translates into the loss of H3K27me3-dependent gene imprinting.
- Seynabou Diop
- Laia Richart
- Raphaël Margueron
