Antibiotic resistance poses a significant threat to global health, necessitating new strategies to combat resistant pathogens. Here, the authors develop triazole analogues targeting the bacterial kinase APH(2”)-IVa, demonstrating promising selectivity, permeability, and moderate efficacy against P. aeruginosa, suggesting a potential pathway to restore the efficacy of aminoglycoside antibiotics.
- Vanessa Buffa
- Julien Kowalewski
- Felix Hausch
