Nature Search

Expression of the c-myb proto-oncogene during cellular proliferation

Craig B. Thompson
Peter B. Challoner
Mark Groudine
Research01 Jan 1986
Nature

Volume: 319, P: 374-380
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

A potent mAb shows promise in monkeys either alone or in a combination therapy for either prophylaxis or treatment of infection with SARS-CoV-2 Omicron BA.1, BA.1.1 and BA.2.

Craig Fenwick
Priscilla Turelli
Giuseppe Pantaleo
ResearchOpen Access25 Jul 2022
Nature Microbiology

Volume: 7, P: 1376-1389
Charcot–Marie–Tooth type 1A duplication appears to arise from recombination at repeat sequences flanking the 1.5 Mb monomer unit

Liu Pentao
Carol A. Wise
James R. Lupski
Research01 Dec 1992
Nature Genetics

Volume: 2, P: 292-300
Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

Epidemics of whooping cough caused by Bordetella pertussis have been seen and are linked to waning immunity globally. Here the authors explore responses to inactivated poliovirus (IPV) in the Tdap-IPV vaccine and show it stimulates early antiviral responses in monocytes and dendritic cells that are associated with long-lived pertussis antibody responses.

Joshua Gillard
Madeleine Suffiotti
Dimitri A. Diavatopoulos
ResearchOpen Access08 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Directional evolution in germline microsatellite mutations

Craig R. Primmer
Hans Ellegren
Anders Pape Møller
Correspondence01 Aug 1996
Nature Genetics

Volume: 13, P: 391-393
Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study

Understanding the immune responses of school-aged children to SARS-CoV-2 is important for designing public health measures. Here, the authors report findings from cross-sectional and longitudinal anti-SARS-CoV-2 antibody measurements in a school-based study in Zurich, Switzerland, from 2020-2022.

Alessia Raineri
Thomas Radtke
Susi Kriemler
ResearchOpen Access27 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

In this study, Marlin et al. provide insights into the potential use of subunit vaccines that induce a high level of protection against SARS-CoV-2 in animal models.

Romain Marlin
Veronique Godot
Roger Le Grand
ResearchOpen Access01 Sept 2021
Nature Communications

Volume: 12, P: 1-9
The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

Infection with SARS CoV2 results in the induction of multiple cytokine and inflammatory pathways. Here the authors demonstrate the association of HGF and CXCL13 production with increased severity and mortality in COVID-19 patients.

Matthieu Perreau
Madeleine Suffiotti
Giuseppe Pantaleo
ResearchOpen Access09 Aug 2021
Nature Communications

Volume: 12, P: 1-10
Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort

The persistence of the immune response to SARS-CoV-2 after recovery from infection is an indicator for subsequent protection against infection. Here the authors follow recovered patients and measure antibody and T cell responses and find that these two parts of the immune response may have different longevity.

Dominik Menges
Kyra D. Zens
Jan S. Fehr
ResearchOpen Access18 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Gilean McVean and colleagues report the results of a large-scale clinical genome sequencing project spanning a broad spectrum of disorders. They identify factors influencing successful genetic diagnosis and highlight the challenges of interpreting findings for genetically heterogeneous disorders.

Jenny C Taylor
Hilary C Martin
Gilean McVean
Research18 May 2015
Nature Genetics

Volume: 47, P: 717-726
Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

Structural genomics and binding studies show that a cyclic peptide produced by Streptomyces griseus, griselimycin, exhibits high binding selectivity for diverse DNA polymerase binding sites of various infectious Gram-negative bacteria.

Michael K. Fenwick
Phillip G. Pierce
Peter J. Myler
ResearchOpen Access05 Dec 2024
Communications Biology

Volume: 7, P: 1-13
Sensitive and frequent identification of high avidity neo-epitope specific CD8⁺ T cells in immunotherapy-naive ovarian cancer

Epithelial ovarian cancer (EOC) has low mutational load. Here the authors analyze circulating and tumor-infiltrating lymphocytes (TILs) from 19 EOC patients and report frequent recovery of neo-antigen-reactive T cells from both compartments but with distinct TCR repertoires that have higher affinity in TILs.

Sara Bobisse
Raphael Genolet
Alexandre Harari
ResearchOpen Access15 Mar 2018
Nature Communications

Volume: 9, P: 1-10
Features of chronic urticaria after COVID-19 mRNA vaccine over time

Schwab et al. evaluate patients with chronic urticaria (CU) in relation to COVID-19 infection and mRNA vaccination. CU post-vaccination was not directly associated with COVID infection nor atopy and initiates independent of vaccine sensitization.

Johan Schwab
Mathilde Foglierini
Yannick D. Muller
ResearchOpen Access30 Nov 2024
Communications Medicine

Volume: 4, P: 1-10
Antibodies to combat viral infections: development strategies and progress

Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for viral infections. This Review describes advances in antibody discovery and engineering that have led to the development of mAbs that target viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respiratory syncytial virus and Ebola virus, and also considers the implications for vaccine development.

Giuseppe Pantaleo
Bruno Correia
Laurent Perez
Reviews20 Jun 2022
Nature Reviews Drug Discovery

Volume: 21, P: 676-696
Measurement of circulating CD21⁻CD27⁻ B lymphocytes in SLE patients is associated with disease activity independently of conventional serological biomarkers

Alice Horisberger
Morgane Humbel
Denis Comte
ResearchOpen Access02 Jun 2022
Scientific Reports

Volume: 12, P: 1-11
Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

Eleonora Ciarlo
Tytti Heinonen
Thierry Roger
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-15

Search

Expression of the c-myb proto-oncogene during cellular proliferation

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Charcot–Marie–Tooth type 1A duplication appears to arise from recombination at repeat sequences flanking the 1.5 Mb monomer unit

Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

Directional evolution in germline microsatellite mutations

Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

Sensitive and frequent identification of high avidity neo-epitope specific CD8⁺ T cells in immunotherapy-naive ovarian cancer

Features of chronic urticaria after COVID-19 mRNA vaccine over time

Antibodies to combat viral infections: development strategies and progress

Measurement of circulating CD21⁻CD27⁻ B lymphocytes in SLE patients is associated with disease activity independently of conventional serological biomarkers

Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

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