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The microscopic structure of quantum defects in 2D materials is crucial to understand their optical properties and spin-photon interface. Here, the authors report the direct imaging of charge state-dependent symmetry breaking of sulfur vacancies and rhenium dopants in 2D MoS₂, showing evidence of a Jahn-Teller effect.

Internet of things (IoT) sensors can collect, store and communicate large volumes of information, which require effective security measures. Here, the authors report the realization of low-power edge sensors based on photosensitive and programmable 2D memtransistors, integrating sensing, storage and encryption functionalities.

The positive thermal expansion exhibited by most materials at increased temperatures is a severe issue for many high precision applications. Here, Xing and co-workers show that redox intercalation of Li ions into a ScF₃framework offers effective control of the thermal expansion for this simple material.

Topological defects play important roles in determining material properties, whilst their core regions remain unexplored due to strongly distorted structures. Zhouet al. take advantage of extended core regions in a chromonic liquid crystal and show both a radial and azimuthal dependent director and scalar order parameter.

Exchange bias occurs in a variety of magnetic materials and heterostructures. The quintessential example occurs in antiferromagnetic/ferromagnetic heterostructures and has been employed extensively in magnetic memory devices. Here, via a specific field training protocol, the authors demonstrate an exchange bias of up to 400mT in odd layered MnBi2Te4.

Plasmodium vivax, the leading cause of human malaria in Asia and Latin America, is thought to have an Asian origin. Here, the authors show that wild chimpanzees and gorillas in Africa are infected with parasites that are closely related to P. vivax, indicating an African origin for this species.

This study demonstrates how point defects in 2D semiconductors can be harnessed for neuromorphic computing. By using random telegraph noise in WSe₂ field-effect transistors, the researchers improve inference accuracy of noise-inflicted medical images.

The selectivity and activity of enzymes is largely attributed to the well-defined cavities around their active sites, defined by the secondary coordination sphere. Here, the authors show that similar strategies may be applied to tune the selectivity of synthetic rhodium hydroformylation catalysts.

Sen et al. report the stacking of a perovskite incipient ferroelectric nanomembrane with atomically thin 2D material for a back-end-of-line compatible ferroelectric-like field effect transistors, functioning as a cryogenic memory at 15 K and as an inference engine at room temperature.

Here, the authors perform a benchmark study of field-effect transistors (FETs) based on 2D transition metal dichalcogenides, i.e., 230 MoS₂ and 160 WS₂ FETs, and track device-to-device variations to gauge the technological viability in future integrated circuits.

Tiers containing graphene-based sensors and molybdenum disulfide-based processors can be vertically stacked using a monolithic integration process, with an interconnect density of 62,500 per mm².

FOXP3 uses the forkhead domain to form a higher-order multimer after binding to T_nG repeat microsatellites.

Monolithic three-dimensional integration of two-dimensional field-effect transistors enables improved integration density and multifunctionality to realize ‘More Moore’ and ‘More than Moore’ technologies.

The relative importance of the mechanisms underlying species radiation remains unclear. Here, the authors combine reference genome assembly and population genetics analyses to show that neutral forces have contributed to the radiation of the most species-rich tree genus Syzygium.

Coherent noise affecting a random error correcting code is now shown to produce a transition between phases that accumulate and destroy magic.

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

By integrating a MoS₂ photodetector with a floating-gate memory device, a nanoscale collision detector can be created that mimics the escape response of the lobula giant movement detector neuron.

A photodiode with bio-plausible event sensing, filtering and adaptation behaviours to replicate the retinal nanostructure and visual pathway is presented, enabling consistent and high-performance machine vision under extreme lighting.

Moiré patterns and flat bands usually occur in multilayer materials with a small interlayer twist angle, but this can cause detrimental lattice reconstruction. Now, flat bands are shown in a bilayer with large twist angle and structural rigidity.

Evidence is shown for a skyrmion-like texture in the layer polarization of the electronic wavefunctions of a twisted two-dimensional material. This provides support for theories that link this spatial texture to the topological properties.

Being able to perform qubit measurements within a quantum circuit and adapt to their outcome broadens the power of quantum computers. These mid-circuit measurements have now been used to implement a cryptographic proof of non-classical behaviour.

Here, the authors demonstrate a wafer-scale, low-temperature process using atomic layer deposition, for the synthesis of uniform, conformal amorphous boron nitride (aBN) thin films. They further fabricate aBN-encapsulated monolayer MoS₂ field-effect transistors.

Jayavelu, Samaha et al., apply machine learning models on hospital admission data, including antibody titers and viral load, to identify patients at high risk for Long COVID. Low antibody levels, high viral loads, chronic diseases, and female sex are key predictors, supporting early, targeted interventions.

Here, the authors observe the lateral confinement of excitons in triangular MoSe₂ quantum dots inside a continuous matrix of monolayer WSe₂. They measure size-dependent exciton confinement in the quantum dots with low-temperature exciton blue shift, and further observe single-photon emission from the smallest dots.

DNA repair in response to DSBs in the preimplantation embryo is hard to analyze. Here the authors show that over 25% of pre-existing heterozygous loci in control single blastomere samples appeared as homozygous after whole genome amplification, therefore, they validated gene editing seen in human embryos in ESCs.

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

This work reports on the synthesis and proximity-induced superconductivity in a topological insulator-based, thin-film heterostructure towards the development of a scalable material platform that could potentially support robust quantum computing.

Square-centimetre scale, multilayer superlattice structures based on atomically thin two-dimensional chalcogenide monolayers enable the realization of excitonic metamaterials.

Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

A new family of tunable microwave dielectrics with unparalleled performance at frequencies up to 125 GHz at room temperature has been created, using dimensionality to add and control a local ferroelectric instability in a system with exceptionally low dielectric loss.

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

The Cancer Genome Atlas Research Network report integrated genomic and molecular analyses of 164 squamous cell carcinomas and adenocarcinomas of the oesophagus; they find genomic and molecular features that differentiate squamous and adenocarcinomas of the oesophagus, and strong similarities between oesophageal adenocarcinomas and the chromosomally unstable variant of gastric adenocarcinoma, suggesting that gastroesophageal adenocarcinoma is a single disease entity.

Tunability of the electronic properties of magnetic topological insulators is highly desired for future device applications. Here, the authors study the effect of substitutional impurities on the topological properties of Sb-doped MnBi₂Te₄ devices and uncover tunable layer-dependent electronic states.

Remote-sensing estimates of fires and the estimated geographic ranges of thousands of plant and vertebrate species in the Amazon Basin reveal that fires have impacted the ranges of 77–85% of threatened species over the past two decades.

PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide a mechanism for PAPP-A substrate binding and selectivity.

CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.

A single-cell ribosome profiling method can provide data at the level of allele-specific ribosome engagement in early development.

NanoLuc substrates with improved solubility and bioavailability, hydrofurimazine and fluorofurimazine, strongly enhance bioluminescence signals in vivo and enable bright dual-color bioluminescent imaging with AkaLuc and AkaLumine.

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

The differentiation of the Earth into mantle and core implies that there is a mechanism to separate iron from silicates. Three-dimensional imaging of samples experimentally subjected to high pressures reveals that liquid iron forms interconnected melt networks at lower mantle conditions, suggesting pathways through which iron can percolate towards the core.

Many-body open quantum systems are predicted to undergo a phase transition towards a pure state through frequent projective measurements. The phases separated by this transition have now been observed with random circuits on a trapped-ion computer.

The effects of genetic variation on DNA methylation patterns are poorly understood. Here, Shi et al.systematically map methylation-quantitative trait loci in lung, breast and kidney tissue to reveal the impact of inherited variation on the human methylome, which also affects cancer risk.

The authors revise the classical view that homeostasis of neuronal activity is achieved by negative firing rate feedback: during sensory deprivation, homeostasis occurs via the sliding threshold, which acts via firing patterns rather than rates.

The ongoing disproportionate increases in temperature and precipitation in the Alaska may alter the latitudinal gradients in greenup and snowmelt timings as well as carbon dynamics. With a broad range of datasets and model results, the authors show that the carbon response to early greenup or delayed snowmelt varies greatly depending upon local climatic limits.

The Amazon rainforest is dominated by relatively few tree species, yet the degree to which this hyperdominance influences carbon cycling remains unknown. Here, the authors analyse 530 forest plots and show that ∼1% of species are responsible for 50% of the aboveground carbon storage and productivity.