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Showing 1–17 of 17 results
Advanced filters: Author: Cuiying Yi Clear advanced filters

  • Immunotherapy holds great potential, although strategies for durable responses against solid tumors are still needed. Here, the authors combine oncolytic virus (OV) engineering and reprogramming of the IL-18 pathway, showing that armed OVs expressing a decoy-resistant IL-18 elicit anti-tumor immunity and long-term immunological memory against multiple refractory tumors in mice.

    • Zhen Fan
    • Ying Liu
    • Jiankai Liang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Structures of the glucagon receptor bound to β-arrestin 1 are reported, providing further information about the arrestin-mediated modulation of G protein-coupled receptors.

    • Kun Chen
    • Chenhui Zhang
    • Beili Wu
    ResearchOpen Access
    Nature
    Volume: 620, P: 904-910

  • The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.

    • Tingting Tang
    • Christin Hartig
    • Beili Wu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ42, humanin, or formyl peptides offer insight into Aβ42 neurotoxicity, humanin neuroprotection, and FPR ligand selectivity

    • Ya Zhu
    • Xiaowen Lin
    • Beili Wu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Cryo-electron microscopy structures of homo- and heterodimers of mGlu2 and mGlu7 provide insights into their dimerization modes and the subunit conformational changes that characterize the activation of these class C G-protein-coupled receptors.

    • Juan Du
    • Dejian Wang
    • Qiang Zhao
    Research
    Nature
    Volume: 594, P: 589-593

  • Formyl peptide receptors (FPRs) are GPCRs that play important roles in transducing chemotactic signals in phagocytes and mediating host-defense and inflammatory responses. Here the authors present the 2.8 Å crystal structure of human FPR2 in complex with the peptide agonist WKYMVm and in combination with molecular docking, ligand-binding and signalling assays provide further insights into the binding modes of FPR2 to both non-formyl and formyl peptides.

    • Tong Chen
    • Muya Xiong
    • Beili Wu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Neuromedin U receptor 2 is an emerging attractive target for treating obesity. Here, a Cryo-EM structure of NmU-25–NMU2–Gi1 provides the structural basis for the designation of highly selective drugs.

    • Wenli Zhao
    • Wenru Zhang
    • Qiang Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands and into the mechanism of CCR5 activation.

    • Hui Zhang
    • Kun Chen
    • Beili Wu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Cryo-electron microscopy structures of the adhesion G protein-coupled receptors ADGRD1 and ADGRF1 provide insight into how these receptors are activated in an intrinsic manner through a ‘stalk’ region that acts as a tethered agonist.

    • Xiangli Qu
    • Na Qiu
    • Beili Wu
    ResearchOpen Access
    Nature
    Volume: 604, P: 779-785

  • The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which is of interest for further drug development.

    • Shuanghong Chen
    • Mengjie Lu
    • Qiang Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • Two X-ray crystal structures are presented of the human P2Y1 G-protein-coupled receptor, which is an important target for anti-thrombotic drugs; the structures unexpectedly reveal two ligand-binding sites.

    • Dandan Zhang
    • Zhan-Guo Gao
    • Beili Wu
    Research
    Nature
    Volume: 520, P: 317-321

  • The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.

    • Haonan Zhang
    • Anna Qiao
    • Beili Wu
    Research
    Nature
    Volume: 553, P: 106-110