Caielli and colleagues performed single-cell RNA sequencing on blood CD4⁺ T cells from pediatric patients with systemic lupus erythematosus and healthy donors, identifying naive, memory, Treg, proliferative and interferon-stimulated gene-high cell subsets. Follicular and peripheral helper T cells, including TH10 cells, and cytotoxic memory cell populations were expanded, along with dysfunctional Treg cells marked by aberrant TLR5 and FCRL3 expression, pointing to links between microbial dysbiosis and impaired immune regulation.
- Preetha Balasubramanian
- Uthra Balaji
- Simone Caielli
