Nature Search

Phase transitions of stored laser-cooled ions

R. Blümel
J. M. Chen
H. Walther
Research01 Jul 1988
Nature

Volume: 334, P: 309-313
Native top-down proteomics enables discovery in endocrine-resistant breast cancer

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

Fabio P. Gomes
Kenneth R. Durbin
John R. Yates III
Research04 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1205-1213
Effects of Sugars on Intestinal Transfer of Amino-acids

H. NEWEY
D. H. SMYTH
Research25 Apr 1964
Nature

Volume: 202, P: 400-401
Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Schief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.

Torben Schiffner
Ivy Phung
William R. Schief
ResearchOpen Access30 May 2024
Nature Immunology

Volume: 25, P: 1073-1082
Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment

The effect of noncoding genetic variation on acute lymphoblastic leukemia treatment response is not fully understood. Here, the authors functionally evaluated variants associated with pharmacological traits and validate the role of rs1247117 in gene regulation impacting therapeutic response.

Kashi Raj Bhattarai
Robert J. Mobley
Daniel Savic
ResearchOpen Access01 May 2024
Nature Communications

Volume: 15, P: 1-14
A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer

The epigenetic mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) are not fully elucidated. Here, the authors reveal a druggable super-enhancer-mediated RNA-binding protein cascade that supports PDAC growth through enhanced mRNA translation.

Corina E. Antal
Tae Gyu Oh
Ronald M. Evans
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia

Different molecular subtypes defined by specific gene rearrangements have been described for acute lymphoblastic leukaemia (ALL). Here, the authors show that ZNF384 fusion activates FLT3 expression conferring a therapeutic vulnerability for ZNF384- rearranged ALL subtype.

Xujie Zhao
Ping Wang
Jun J. Yang
ResearchOpen Access14 Sept 2022
Nature Communications

Volume: 13, P: 1-11
Potential impacts of climate change on agriculture and fisheries production in 72 tropical coastal communities

Responses of agriculture and fisheries to climate change are interlinked, yet rarely studied together. Here, the authors analyse more than 3000 households from 5 tropical countries and forecast mid-century climate change impacts, finding that communities with higher fishery dependence and lower socioeconomic status communities face greater losses.

Joshua E. Cinner
Iain R. Caldwell
Richard Pollnac
ResearchOpen Access05 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity

Here, the authors show that anchoring of the PRC2 complex to its own sites requires nuclear condensation of Ccc1, a H3K27me3 reader in the yeast Cryptococcus neoformans, suggesting a functional role for condensates in ensuring heterochromatin fidelity.

Sujin Lee
Stephen Abini-Agbomson
Hiten D. Madhani
Research22 May 2023
Nature Structural & Molecular Biology

Volume: 30, P: 891-901
Mitochondrial RNA stimulates beige adipocyte development in young mice

Hoang et al. show that mitochondrial RNA in young beige adipocytes triggers mitobiogenesis and thermogenesis, while an interferon response is avoided through vitamin D-mediated suppression of IRF7 expression.

Anh Cuong Hoang
László Sasi-Szabó
Tamás Röszer
ResearchOpen Access28 Nov 2022
Nature Metabolism

Volume: 4, P: 1684-1696
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

The SARS-CoV-2 nucleocapsid (N) protein binds the viral RNA genome and contains two ordered domains flanked by three intrinsically-disordered regions. Here, the authors show that RNA binding induces liquid-liquid phase separation of N, which is driven by its central intrinsically-disordered region and is modulated by phosphorylation. The SARS-CoV-2 Membrane (M) protein also phase-separates with N, and three-component mixtures of N + M + RNA form mutually exclusive compartments containing N + M or N + RNA.

Shan Lu
Qiaozhen Ye
Kevin D. Corbett
ResearchOpen Access21 Jan 2021
Nature Communications

Volume: 12, P: 1-15
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia

Autry et al. combine genome-wide genomic, epigenetic and transcriptomic analyses in an integrated polygenomic approach to identify mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia.

Robert J. Autry
Steven W. Paugh
William E. Evans
Research09 Mar 2020
Nature Cancer

Volume: 1, P: 329-344
Directed conservation of the world’s reef sharks and rays

A survey of sharks and rays on coral reefs within 66 marine protected areas across 36 countries showcases that the conservation benefits of full MPA protection to sharks almost double when accompanied by effective fisheries management.

Jordan S. Goetze
Michael R. Heithaus
Demian D. Chapman
Research20 May 2024
Nature Ecology & Evolution

Volume: 8, P: 1118-1128
Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

The antitumor drug trabectedin is more toxic to DNA-repair-proficient cells. Here the authors show that this is caused by persistent DNA breaks induced from an abortive repair reaction and develop “TRABI-Seq” to map the breaks to transcribed regions of the genome. Trabectedin may thus be used as a diagnostic and therapeutic in precision oncology.

Kook Son
Vakil Takhaveev
Orlando D. Schärer
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Integrated multi-omics framework of the plant response to jasmonic acid

Five genome-wide approaches are integrated to give a comprehensive picture of jasmonic acid signalling networks in Arabidopsis. New genes, validated by mutant analysis, and important connections with other pathways are revealed.

Mark Zander
Mathew G. Lewsey
Joseph R. Ecker
Research13 Mar 2020
Nature Plants

Volume: 6, P: 290-302
Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Torben Schiffner
Ivy Phung
William R. Schief
Amendments and CorrectionsOpen Access14 Jun 2024
Nature Immunology

Volume: 25, P: 1307
Quantum optical tests of complementarity

Marian O. Scully
Berthold-Georg Englert
Herbert Walther
Reviews09 May 1991
Nature

Volume: 351, P: 111-116
Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis

Shridhar Bale
Elena Gustchina
Richard T. Wyatt
ResearchOpen Access20 Aug 2025
npj Vaccines

Volume: 10, P: 1-15
Tuning of the Electro-Optical Properties of Tetraphenylcyclopentadienone via Substitution of Oxygen with Sterically-Hindered Electron Withdrawing Groups

Carmine Coluccini
Puliparambil Thilakan Anusha
Yit Lung Khung
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-14
Digestion and depletion of abundant proteins improves proteomic coverage

Improved mass spectrometry–based detection of low-abundance proteins in complex proteomes is made possible with a method to selectively digest and deplete high-abundance proteins.

Bryan R Fonslow
Benjamin D Stein
John R Yates III
Research01 Jan 2013
Nature Methods

Volume: 10, P: 54-56
High gold concentrations in sulphide-bearing magma under oxidizing conditions

Magma transports metals to the Earth’s surface to form ore deposits, but only sulphide-undersaturated magmas were thought to be capable of generating large amounts of ore. Laboratory experiments indicate that large volumes of gold ore can also be generated by sulphide-saturated magma, if the redox conditions of the magma are suitable.

Roman E. Botcharnikov
Robert L. Linnen
Jasper Berndt
Research19 Dec 2010
Nature Geoscience

Volume: 4, P: 112-115
A phase I trial of a single high dose of idarubicin combined with high-dose cytarabine as induction therapy in relapsed or refractory adult patients with acute lymphoblastic leukemia

MA Weiss
P Drullinsky
DW Golde
Research04 Jun 1998
Leukemia

Volume: 12, P: 865-868
Estimated 6-year event-free survival of 55% in 60 consecutive adult acute lymphoblastic leukemia patients treated with an intensive phase II protocol based on high induction dose of daunorubicin

G Todeschini
C Tecchio
G Perona
Research28 Apr 1998
Leukemia

Volume: 12, P: 144-149
Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin

Mackenzie K. Herroon
Erandi Rajagurubandara
Izabela Podgorski
ResearchOpen Access08 Jan 2018
Scientific Reports

Volume: 8, P: 1-16
Allogeneic or autologous stem cell transplantation following salvage chemotherapy for adults with refractory or relapsed acute lymphoblastic leukemia

R Martino
M Bellido
J Sierra
Research14 May 1998
Bone Marrow Transplantation

Volume: 21, P: 1023-1027
The hyper-CVAD regimen improves outcome in relapsed acute lymphoblastic leukemia

CA Koller
HM Kantarjian
M Keating
Research01 Dec 1997
Leukemia

Volume: 11, P: 2039-2044
Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia

Brennan P. Bergeron
Jonathan D. Diedrich
Daniel Savic
ResearchOpen Access26 Aug 2022
Leukemia

Volume: 36, P: 2374-2383
Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics

C Wuchter
L Karawajew
W-D Ludwig
Research02 Dec 1999
Leukemia

Volume: 13, P: 1943-1953
Impact of alcohol exposure on neural development and network formation in human cortical organoids

Jason W. Adams
Priscilla D. Negraes
Cleber A. Trujillo
ResearchOpen Access16 Nov 2022
Molecular Psychiatry

Volume: 28, P: 1571-1584
Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy

Priscilla D. Negraes
Cleber A. Trujillo
Alysson R. Muotri
ResearchOpen Access22 Apr 2021
Molecular Psychiatry

Volume: 26, P: 7047-7068
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Jorge Urresti
Pan Zhang
Lilia M. Iakoucheva
ResearchOpen Access26 Aug 2021
Molecular Psychiatry

Volume: 26, P: 7560-7580
Heart rate variability in congenital central hypoventilation syndrome: relationships with hypertension and sinus pauses

Benjamin Dudoignon
Isabelle Denjoy
Christophe Delclaux
Research26 Jul 2022
Pediatric Research

Volume: 93, P: 1003-1009
High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study

C Chabannon
K Cornetta
P Viens
Research01 Oct 1998
British Journal of Cancer

Volume: 78, P: 913-921
Cohort design and natural language processing to reduce bias in electronic health records research

Shaan Khurshid
Christopher Reeder
Steven A. Lubitz
ResearchOpen Access08 Apr 2022
npj Digital Medicine

Volume: 5, P: 1-14
Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks

Jonathan D. Diedrich
Qian Dong
Daniel Savic
Research13 Mar 2021
Leukemia

Volume: 35, P: 3078-3091
Orchestration of gene expression across the seasons: Hypothalamic gene expression in natural photoperiod throughout the year in the Siberian hamster

Ines Petri
Victoria Diedrich
Perry Barrett
ResearchOpen Access11 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation

S E Wheeler
S Suzuki
J R Grandis
Research12 Jul 2010
Oncogene

Volume: 29, P: 5135-5145
Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes

S Bidel
K Silventoinen
J Tuomilehto
Research07 Mar 2007
European Journal of Clinical Nutrition

Volume: 62, P: 178-185
Plant growth improvement mediated by nitrate capture in co-composted biochar

Claudia I. Kammann
Hans-Peter Schmidt
Stephen Joseph
ResearchOpen Access09 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
Quantitative assessment of central and limbal epithelium after long-term wear of soft contact lenses and in patients with dry eyes: a pilot study

R K Prakasam
B S Kowtharapu
O Stachs
Research22 Apr 2016
Eye

Volume: 30, P: 979-986
Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer

Growth-hormone-releasing hormone (GHRH) and its receptors are expressed in a wide variety of normal and malignant tissues. This article describes various GHRH antagonists, their mechanisms of action, andin vivostudies. These antagonists are a promising potential therapy for a wide range of cancers, and perhaps other diseases.

Andrew V Schally
Jozsef L Varga
Jörg B Engel
Reviews01 Jan 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 33-43
Correction: Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks

Jonathan D. Diedrich
Qian Dong
Daniel Savic
Amendments and Corrections03 Jul 2024
Leukemia

Volume: 38, P: 1867
Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans

Karsten Heusser
Jens Tank
Jens M. Hohlfeld
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Manipulation of MHC-I/TCR Interaction for Immune Therapy

Qingjun Liu
Bin Gao
Reviews01 Jun 2008
Cellular & Molecular Immunology

Volume: 5, P: 171-182
Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy

M Favrot
J-L Coll
A Negoescu
Reviews18 Jun 1998
Gene Therapy

Volume: 5, P: 728-739
Correction: Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Jorge Urresti
Pan Zhang
Lilia M. Iakoucheva
Amendments and Corrections21 Sept 2021
Molecular Psychiatry

Volume: 26, P: 7581
The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation

E M Weissinger
C Human
M Stadler
Research28 Sept 2016
Leukemia

Volume: 31, P: 654-662
Phase I/II trial of multicycle high-dose chemotherapy with peripheral blood stem cell support for treatment of advanced ovarian cancer

N Frickhofen
W E Berdel
V Möbus
Research21 Aug 2006
Bone Marrow Transplantation

Volume: 38, P: 493-499
Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host disease after allogeneic stem cell transplantation

E M Weissinger
J Metzger
A Ganser
ResearchOpen Access11 Jul 2013
Leukemia

Volume: 28, P: 842-852

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