Nature Search

A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer

Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastatic spread. These seemingly opposing functions are a result of the requirement of STAT3 for stimulator of interferon genes–interferon signaling in metastasis and the authors show how it can be targeted in mice.

Aleks C. Guanizo
Quinton Luong
Daniel J. Gough
Research21 Nov 2024
Nature Immunology

Volume: 25, P: 2259-2269
CD14 Modulates PI3K/AKT/p38-MAPK Licensing of Negative Regulators of TLR Signaling to Restrain Chronic Inflammation

Bikash Sahay
Rebeca Patsey
Timothy Sellati
ResearchOpen Access25 Jun 2008
Nature Precedings

P: 1
Upper-crustal strength inferred from stress measurements to 6 km depth in the KTB borehole

Mark D. Zoback
R. Apel
L. Vernik
Research01 Oct 1993
Nature

Volume: 365, P: 633-635
The role of non-deformable units in pressure-induced reversible amorphization of clathrasils

J. S. Tse
D. D. Klug
K. Lagarec
Research30 Jun 1994
Nature

Volume: 369, P: 724-727
Weak neutral currents and the origin of biomolecular chirality

D. K. Kondepudi
G. W. Nelson
Research01 Apr 1985
Nature

Volume: 314, P: 438-441
Limits to palaeogravity since the late Precambrian

A. D. STEWART
Research12 Jan 1978
Nature

Volume: 271, P: 153-155
Carbon–fluid equilibria and the oxidation state of the upper mantle

Jonathan D. Blundy
John P. Brodholt
Bernard J. Wood
Research24 Jan 1991
Nature

Volume: 349, P: 321-324
A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs

3D scaffolds can be used to recapitulate key aspects of the microenvironment of primary tumors and metastatic organs. Here the authors use subcutaneous porous 3D scaffold implants as a tool to study the immune signals in the lungs of metastatic breast cancer, revealing multifaceted roles of neutrophils in regulating lung metastasis.

Jing Wang
Ramon Ocadiz-Ruiz
Lonnie D. Shea
ResearchOpen Access08 Aug 2023
Nature Communications

Volume: 14, P: 1-20
Microvilli and cell swelling

S. KNUTTON
D. JACKSON
C. A. PASTERNAK
Research01 Jul 1976
Nature

Volume: 262, P: 52-54
Delayed phase change due to hot asthenosphere causes Transantarctic uplift?

A. G. Smith
D. J. Drewry
Research07 Jun 1984
Nature

Volume: 309, P: 536-538
Plate Motions relative to the Deep Mantle and the Development of Subduction Zones

R. D. HYNDMAN
Research04 Aug 1972
Nature

Volume: 238, P: 263-265
Assembly of porphyrin building blocks into network structures with large channels

B. F. Abrahams
B. F. Hoskins
R. Robson
Research30 Jun 1994
Nature

Volume: 369, P: 727-729
Effects of altered [ADP-ribose]_n metabolism on expression of fetal functions by adult hepatocytes

Felix R. Althaus
Susan D. Lawrence
Henry C. Pitot
Research25 Nov 1982
Nature

Volume: 300, P: 366-368
Fitness costs of gestation and lactation in wild mammals

T. H. Clutton-Brock
S. D. Albon
F. E. Guinness
Research19 Jan 1989
Nature

Volume: 337, P: 260-262
Effect of energetic ions on edge-localized modes in tokamak plasmas

Edge-localized plasma modes in a tokamak can damage its innermost wall. Simulations now show that fast ions can modify the spatio-temporal structure of these modes. These effects need to be considered in the optimization of control techniques.

J. Dominguez-Palacios
S. Futatani
M. Zuin
ResearchOpen Access06 Jan 2025
Nature Physics

Volume: 21, P: 43-51
The IX-α Structure of the Common Bile Pigments

C. H. GRAY
D. C. NICHOLSON
R. A. NICOLAUS
Research18 Jan 1958
Nature

Volume: 181, P: 183-185
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.

Christina K. Baumgartner
Hakimeh Ebrahimi-Nik
Robert T. Manguso
ResearchOpen Access04 Oct 2023
Nature

Volume: 622, P: 850-862
G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells

Few therapeutic options are available for patients with Neurofibromatosis Type II. Here, the authors identify G6PD as a potential pharmacological target and show that NF2 mutant Schwann cells are in an oxidized state and die when G6PD is inhibited.

Athena Kyrkou
Robert Valla
Aurelio A. Teleman
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Production of methane and carbon dioxode from methane thiol and dimethyl sulphide by anaerobic lake sediments

STEPHEN H. ZINDER
T. D. BROCK
Research18 May 1978
Nature

Volume: 273, P: 226-228
Fuel–Coolant Interactions in Submarine Vulcanism

R. S. PECKOVER
D. J. BUCHANAN
D. E. T. F. ASHBY
Research01 Oct 1973
Nature

Volume: 245, P: 307-308
Recent dyke-induced large-scale block movement at Mount Etna and potential slope failure

W. J. McGuire
A. D. Pullen
S. J. Saunders
Research25 Jan 1990
Nature

Volume: 343, P: 357-359
The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

Human and mouse cells expressing a redox-insensitive GAPDH mutant that otherwise retains its catalytic activity are shown to be unable to upregulate the oxidative pentose phosphate pathway in response to oxidative stress.

Deepti Talwar
Colin G. Miller
Tobias P. Dick
ResearchOpen Access06 Apr 2023
Nature Metabolism

Volume: 5, P: 660-676
Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Cancer vaccines that self-assemble into uniform nanoparticles improve tumor clearance.

Geoffrey M. Lynn
Christine Sedlik
Robert A. Seder
Research13 Jan 2020
Nature Biotechnology

Volume: 38, P: 320-332
Evidence for Single Copies of Globin Genes in the Mouse Genome

PAUL R. HARRISON
ANNA HELL
JOHN PAUL
Research22 Sept 1972
Nature

Volume: 239, P: 219-221
The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

Ulrike Beisiegel
Wilfried Weber
Keith K. Stanley
Research14 Sept 1989
Nature

Volume: 341, P: 162-164
Effects of Different Endogone Strains on the Growth of Paspalum notatum

BARBARA MOSSE
Research22 Sept 1972
Nature

Volume: 239, P: 221-223
Microearthquake survey of Median Valley of the Mid-Atlantic ridge at 36°30′N

R. C. SPINDEL
S. B. DAVIS
J. D. PHILLIPS
Research12 Apr 1974
Nature

Volume: 248, P: 577-579
A ketogenic diet rich in fish oil is superior to other fats in preventing NNK-induced lung cancer in A/J mice

Ingrid Elisia
Michelle Yeung
Gerald Krystal
ResearchOpen Access07 Mar 2024
Scientific Reports

Volume: 14, P: 1-15
The intraflagellar transport cycle

Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facilitates cargo import, whereas remodelling into a retrograde train at the ciliary tip enables cargo export.

Samuel E. Lacey
Gaia Pigino
Reviews13 Nov 2024
Nature Reviews Molecular Cell Biology

Volume: 26, P: 175-192
Thickness of ice on perennially frozen lakes

Christopher P. McKay
Gary D. Clow
Steven W. Squyres
Research01 Feb 1985
Nature

Volume: 313, P: 561-562
Effects of Chronic Protein-Calorie Malnutrition on Small Intestinal Repair after an Acute Bacterial Enteritis: A Study in Infant Rabbits

J Decker Butzner
D Grant Gall
Research01 Apr 1988
Pediatric Research

Volume: 23, P: 408-413
A collaboratively derived international research agenda on legislative science advice

Karen Akerlof
Chris Tyler
Masaru Yarime
ResearchOpen Access17 Sept 2019
Palgrave Communications

Volume: 5, P: 1-13
No meridional plasma flow in the heliosheath transition region

The radially outward flow of plasma from the Sun is expected to be deflected when it meets the flow of interstellar plasma through which the Solar System moves, but the spacecraft Voyager 1 unexpectedly finds that the deflected, meridional, flow is consistent with zero within the transition region.

Robert B. Decker
Stamatios M. Krimigis
Matthew E. Hill
Research05 Sept 2012
Nature

Volume: 489, P: 124-127
The temporal dynamics of lncRNA Firre-mediated epigenetic and transcriptional regulation

Typically, lncRNA perturbations are measured on the timescale of many hours to days. Here, the authors investigate when and where the lncRNA Firre influences epigenetic and transcriptional states, suggesting that lncRNA-mediated gene regulation occurs within minutes and is retained for days.

Christian Much
Erika L. Lasda
John L. Rinn
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Lymphocyte-mediated Transport of Aggregated Human γ-Globulin into Germinal Centre Areas of Normal Mouse Spleen

J. C. BROWN
D. G. DE JESUS
G. HARRIS
Research24 Oct 1970
Nature

Volume: 228, P: 367-369
The Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer

Identifying actionable biomarkers remains a challenge. Here, the authors develop a framework Oncology Biomarker Discovery (OncoBird), apply it to a phase III trial and investigate the molecular and biomarker landscape of metastatic colorectal carcinoma patients.

Alexander J. Ohnmacht
Arndt Stahler
Michael P. Menden
ResearchOpen Access04 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Authoritarianism as pathology of recognition: the sociological substance and actuality of the authoritarian personality

Benno Herzog
ResearchOpen Access04 Jun 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-9
Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses

The local X-ray-induced dynamics that occur in protein crystals during serial femtosecond crystallography (SFX) measurements at XFELs are not well understood. Here the authors performed a time-resolved X-ray pump X-ray probe SFX experiment, and they observe distinct structural changes in the disulfide bridges and peptide backbone of proteins; complementing theoretical approaches allow them to further characterize the details of the X-ray induced ionization and local structural dynamics.

Karol Nass
Alexander Gorel
Ilme Schlichting
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-9
An independent microbial flora of the epithelium and its role in the ecomicrobiology of the rumen

R. J. WALLACE
K.-J. CHENG
E. R. ØRSKOV
Research01 May 1979
Nature

Volume: 279, P: 424-426
Mediation of the solar wind termination shock by non-thermal ions

Data from the plasma and magnetic field instruments on Voyager 2 indicate that non-thermal ion distributions probably play key roles in mediating dynamical processes at the termination shock and in the heliosheath. Intensities of low-energy ions measured at Voyager 2 produce non-thermal partial ion pressures in the heliosheath that are comparable to (or exceed) both the thermal plasma pressures and the scalar magnetic field pressures. The acceleration of ions extracts a large fraction of bulk flow kinetic energy from the incident solar wind.

R. B. Decker
S. M. Krimigis
L. J. Lanzerotti
Research03 Jul 2008
Nature

Volume: 454, P: 67-70
Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures

Recent advances in tissue engineering have been remarkable, yet the precise control of cellular behavior in 2D and 3D cultures remains challenging. Here by using light signals, they spatially regulated programmed cell death pathways and cell-cell communication cascades in 2- and 3-dimensional designer tissues.

Hannes M. Beyer
Sant Kumar
Matias D. Zurbriggen
ResearchOpen Access02 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

Hongu et al. find that perivascular macrophages stimulate activation of the pro-metastatic vascular niche via tenascin C stimulation of TLR4 and show that combined TLR4 and VEGF inhibition prevents TNC-mediated metastatic vascular activity.

Tsunaki Hongu
Maren Pein
Thordur Oskarsson
ResearchOpen Access25 Apr 2022
Nature Cancer

Volume: 3, P: 486-504
Identification and analysis of a bottleneck in PCB biodegradation

Shaodong Dai
Frédéric H. Vaillancourt
Lindsay D. Eltis
Research04 Nov 2002
Nature Structural Biology

Volume: 9, P: 934-939
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Adriana Donovan
Alison Brownlie
Leonard I. Zon
Research17 Feb 2000
Nature

Volume: 403, P: 776-781
Distribution of energetic particles near interplanetary shocks

A. Hewish
S. Bravo
Research06 Nov 1986
Nature

Volume: 324, P: 44-46
Decrease of Thymic Hormone Serum Level in Cockayne Syndrome

Albert Bensman
Mireille Dardenne
Géraud Lasfargues
Research01 Feb 1982
Pediatric Research

Volume: 16, P: 92-94
Erratum: Antibody neutralization and escape by HIV-1

Xiping Wei
Julie M. Decker
George M. Shaw
Amendments and Corrections08 May 2003
Nature

Volume: 423, P: 197
Antibody neutralization and escape by HIV-1

Xiping Wei
Julie M. Decker
George M. Shaw
Research20 Mar 2003
Nature

Volume: 422, P: 307-312
Early cave art and ancient DNA record the origin of European bison

The ancestry of the European bison (wisent) remains a mystery. Here, Cooper and colleagues examine ancient DNA from fossil remains of extinct bison, and reveal the wisent originated through the hybridization of the extinct Steppe bison and ancestors of modern cattle.

Julien Soubrier
Graham Gower
Alan Cooper
ResearchOpen Access18 Oct 2016
Nature Communications

Volume: 7, P: 1-7
Engineering enhanced cellobiohydrolase activity

Cellobiohydrolases (CBHs) are critical for natural and industrial biomass degradation but their structure–activity relationships are not fully understood. Here, the authors present the biochemical and structural characterization of two CBHs, identifying protein regions that confer enhanced CBH activity.

Larry E. Taylor II
Brandon C. Knott
Gregg T. Beckham
ResearchOpen Access22 Mar 2018
Nature Communications

Volume: 9, P: 1-10

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