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Entangled quantum memories are used in a quantum network of silicon–vacancy centres in diamond nanocavities to experimentally perform non-local phase measurements.

A programmable three-layer photonic platform implements large-scale unitary transformations, distributing the input field into thousands of output modes for scalable photonic information processing in free space.

A general protocol for high-dimensional entangling gates is developed and applied for two four-dimensional qudits encoded in orbital angular momentum (OAM). The phase-locking technique stabilizes OAM sorters, leading to a process fidelity within a range from 0.71 to 0.85.

Understanding the nature of coherent absorption is essential for exploiting it in new technologies. Here, the authors show that a metamaterial can deterministically absorb photons from a travelling wave with nearly unitary probability, down to the single-photon level.

Single-photon W-states — coherent superpositions of all qubits with equal probability amplitudes — involving up to 16 spatial modes are generated by means of evanescently-coupled waveguide technology. A scheme capable of exploiting the maximal entanglement of W-states is proposed for the efficient generation of random numbers.

The distribution of quantum computations is demonstrated between two photonically interconnected trapped-ion modules, using repeatable, deterministic teleported controlled-Z gates to perform Grover’s search algorithm.

A manufacturable platform for quantum computing with photons is introduced and a set of monolithically integrated silicon-photonics-based modules is benchmarked, demonstrating dual-rail photonic qubits with performance close to thresholds required for operation.

A large sulfur-bearing carbon ring molecule has been detected in space, 2,5-cyclohexadien-1-thione, using laboratory spectroscopy and a radio telescope. Found near the Galactic Centre, it opens the door to a new family of interstellar molecules.

Many quantum devices operate in the microwave regime, but long-distance communication relies on optical photons. A nanomechanical resonator can be used to create entangled optical and microwave photons linking the two frequency regimes.

This Review explores in detail the complexity of NK cell biology in humans and highlights the role of these cells in cancer immunity.

Spreading depression is a slowly propagating wave of mass depolarization that successively engulfs contiguous brain regions, causing transient neuronal hyperexcitability at its leading edge, followed by complete but reversible neuronal silence lasting minutes. Here, the authors present an evidence-based view of spreading depression as a probable cause of characteristic neurological signs and symptoms in numerous neurological conditions.

An ultra-low-loss integrated photonic chip fabricated on a customized multilayer silicon nitride 300-mm wafer platform, coupled over fibre with high-efficiency photon number resolving detectors, is used to generate Gottesman–Kitaev–Preskill qubit states.

A three-photon entangled Greenberger–Horne–Zeilinger state is directly produced by cascading two entangled down-conversion processes. Experimentally, 11.1 triplets per minute are detected on average. The three-photon entangled state is used for state tomography and as a test of local realism by violating the Mermin and Svetlichny inequalities.

Hyper-complex quantum theories are generalizations of quantum mechanics where amplitudes are generalized complex numbers. Here the authors study phase commutation in a photonic experiment, reporting consistency with standard quantum mechanics and placing precise bounds on hyper-complex theories.

A transducer that generates microwave–optical photon pairs is demonstrated. This could provide an interface between optical communication networks and superconducting quantum devices that operate at microwave frequencies.

T-cell acute lymphoblastic leukemia is a highly aggressive disease with varying recurrence rates. Here, the authors build a single cell transcriptomic atlas of childhood T-cell acute lymphoblastic leukaemia (T-ALL). They identified a distinctive cancer cell state that correlates with high risk, treatment refractory T-ALL.

An entanglement filter based on Rydberg atoms is demonstrated. It transmits a desired photonic entangled state and blocks unwanted ones. Near-perfect photonic entanglement can be extracted from a noisy input with arbitrarily low initial fidelity.

The evolution of a quantum state undergoing radiative decay depends on how the emission is detected. Here, the authors demonstrate how continuous field detection, as opposed to the more common detection of energy quanta, allows control of the back-action on the emitter’s state.

Monitoring the activity of nuclear reactors requires measuring the neutron distribution in the core efficiently and in real time. Here, the authors present an imaging approach for neutrons and gamma-rays that thanks to a slit-pupil-like design, enables radiations to be visualized directly in operative reactors.

McConnell et al. develop TANGERINE, a computationally frugal, open-source foundation model for analyzing 3D low-dose chest computed tomography (CT) scans. The model achieves strong generalisation and label efficiency across multiple lung diseases while requiring minimal computational resources.

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Entanglement of two nanophotonic quantum network nodes is demonstrated through 40  km spools of low-loss fibre and a 35-km long fibre loop deployed in the Boston area urban environment.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.

A proof-of-principle study reports a complete photonic quantum computer architecture that can, once appropriate component performance is achieved, deliver a universal and fault-tolerant quantum computer.

Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and identifies brain–body dynamics as a potential target for intervention.

A fault-tolerant, universal set of single- and two-qubit quantum gates is demonstrated between two instances of the seven-qubit colour code in a trapped-ion quantum computer.

No noncontextual hidden-variable model can be consistent with quantum theory, but proving such an inconsistency with nature itself is a long-standing problem. Here, the authors devise experimentally-achievable tests of noncontextuality and perform a photonic implementation that rules out such models.

Tailoring of arbitrary single-mode states of travelling light up to the two-photon level is proposed and demonstrated. The desired state is remotely prepared in the signal channel of spontaneous parametric down-conversion by means of conditional measurements on the idler channel.

It has been conjectured that not only states but also quantum operations can be placed in a superposition of causal order. Here, the authors use a qubit superpose the order in which two photonic gates are applied, which is shown to enable a more efficient detection of their commutation relations.

This study demonstrates the experimental realization of a complete protocol for quantum key distribution using entangled trapped strontium ions with device-independent quantum security guarantees.

Doan et al. show that loss of cardiac NAD⁺ is sufficient to drive metabolic derangements, hypertrophic remodeling and lethal arrhythmias in adult mouse hearts, despite maintenance of ejection fraction and bioenergetics.

Here, the authors report the observation of two solid-state analogues of well-known high-energy physics effects in graphene samples irradiated by infrared photons under non-equilibrium conditions. Depending on the carrier density of graphene, they observed asymmetric plasmon damping, and anomalous photocurrents associated with the condensed matter versions of the Cherenkov and Schwinger effects.

Spectral Denoising removes chemical and electronic noise from mass spectrometry data to improve metabolite annotation.

A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.

Two studies of electrons generated from laser-triggered emitters have found highly predictable electron–electron energy correlations. These studies, at vastly different energy scales, may lead to heralded electron sources, enabling quantum free-electron optics and low-noise, low-damage electron beam lithography and microscopy.

A protocol to recover states of optical continuous-variable entanglement is developed based on approximate heralded noiseless amplification. The degraded entanglement is completely recovered no matter how significant these losses are.

By using a five-qubit error-correcting code with a recently discovered flag protocol, a logical qubit that is operated fault-tolerantly is realized based on solid-state spin qubits in diamond.

High-dimensional quantum states allow for several advantages in quantum communication, but protocols such as teleportation require additional entangled photons as the dimension increases. Here, the authors show how to transport a high-dimensional quantum state from a bright coherent laser field to a single photon, using two entangled photons as the quantum channel.

Immune-mediated inflammatory diseases such as rheumatoid arthritis (RA) are characterised by relapsing-remitting flares, which are difficult to study due to their unpredictable nature. Here the authors use an experimental model of immunomodulatory drug cessation in RA patients combined with multi-omic analysis of circulating leukocytes to characterise the immune response for those with arthritis flare versus drug-free remission.

Lung cancer screening (LCS) requires effectively and efficiently mining big, multimodal datasets. Here, the authors develop a medical multimodal-multitask foundation model (M3FM) for LCS from 3D low-dose computed tomography and medical multimodal data, outperforming state-of-the-art methods and allowing the identification of informative data elements.