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Showing 1–9 of 9 results
Advanced filters: Author: D. J. MacAllister Clear advanced filters

  • Using a non-human primate model, the authors identified the tissue sites of initial viral rebound after discontinuation of antiretroviral therapy, demonstrating that such rebound preferentially occurs in the gastrointestinal tract-associated lymphoid tissues.

    • Brandon F. Keele
    • Afam A. Okoye
    • Louis J. Picker
    ResearchOpen Access
    Nature Microbiology
    P: 1-16

  • Nav1.7 channels are known to regulate pain perception in humans and mice. Here, the authors provide evidence that Nav1.7 deletion leads to transcriptional upregulation of opioid peptides in sensory neurons, and that treatment with the opioid blocker naloxone helps reverse analgesia in mice and human Nav1.7 nulls.

    • Michael S. Minett
    • Vanessa Pereira
    • John N. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Observations suggest early twentieth-century human activities, in the form of canal construction, increased groundwater availability in northwest India and Pakistan, in contrast to recent depletion driven by tubewell development and low rainfall.

    • D. J. MacAllister
    • G. Krishan
    • A. M. MacDonald
    Research
    Nature Geoscience
    Volume: 15, P: 390-396

  • The authors compared the performance of a range of rural water supply types during drought in Ethiopia. They show that prioritising access to groundwater via multiple improved water sources and technologies, such as hand-pumped and motorised boreholes, supported by monitoring and proactive operation and maintenance increases rural water supply resilience.

    • D. J. MacAllister
    • A. M. MacDonald
    • R. Calow
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta.

    • Alec J. Hirsch
    • Victoria H. J. Roberts
    • Daniel N. Streblow
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem cell transplantation that mimics diverse clinical outcomes of human allo-HSCT.

    • Benjamin J. Burwitz
    • Helen L. Wu
    • Jonah B. Sacha
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • The current guidelines for prevention of cardiovascular disease are based on estimates of long-term risk. Smeeth and Hingorani recommend awareness of the importance of fluctuations of risk over short periods of time and suggest a new paradigm for management of cardiovascular disease that is based on targeting therapy to short periods of enhanced risk.

    • Liam Smeeth
    • Aroon D. Hingorani
    Reviews
    Nature Reviews Cardiology
    Volume: 7, P: 409-411