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Showing 1–50 of 60 results

Advanced filters: Author: Dana Mueller Clear advanced filters

The molecular basis of the human serum paraoxonase activity polymorphism

Richard Humbert
David A. Adler
Clement E. Furlong
Research01 Jan 1993
Nature Genetics

Volume: 3, P: 73-76
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

The authors designed stapled antimicrobial peptides that have potent antibacterial activity in mice and limited toxicity.

Rida Mourtada
Henry D. Herce
Loren D. Walensky
Research19 Aug 2019
Nature Biotechnology

Volume: 37, P: 1186-1197
Limited overlap between genetic effects on disease susceptibility and disease survival

Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

Zhiyu Yang
Fanny-Dhelia Pajuste
Andrea Ganna
ResearchOpen Access30 Sept 2025
Nature Genetics

Volume: 57, P: 2418-2426
Methicillin resistant Staphylococcus aureus mazEF expression promotes infections by influencing cellular growth, antibiotic sensitivity, and formation of biofilms

Jonathan B. Mandell
Charles Gish
Kenneth L. Urish
ResearchOpen Access11 Sept 2024
Scientific Reports

Volume: 14, P: 1-8
Simultaneous enhancement of multiple functional properties using evolution-informed protein design

A major challenge in protein design is to augment existing functional proteins with multiple property enhancements. Here the authors use the evolutionary model EVcouplings to computationally design highly mutated variants of TEM-1 ß-lactamase, and characterise these designs experimentally.

Benjamin Fram
Yang Su
Nicholas P. Gauthier
ResearchOpen Access20 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

T. H. Finkel
G. Tudor-Williams
A. Kupfer
Research01 Feb 1995
Nature Medicine

Volume: 1, P: 129-134
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia

B U Mueller
T Pabst
D G Tenen
ResearchOpen Access30 May 2006
British Journal of Cancer

Volume: 94, P: 1918-1920
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.

Adela S. Oliva Chávez
Xiaowei Wang
Joao H. F. Pedra
ResearchOpen Access17 Jun 2021
Nature Communications

Volume: 12, P: 1-17
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Keith Ligon, Adam Resnick, Rameen Beroukhim and colleagues identify MYB-QKI fusions in angiocentric gliomas and show that these rearrangements promote tumorigenesis through activation of MYB by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of QKI.

Pratiti Bandopadhayay
Lori A Ramkissoon
Adam C Resnick
Research01 Feb 2016
Nature Genetics

Volume: 48, P: 273-282
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

Tucker Collins
David Ginsburg
Jordan S. Pober
Research22 Aug 1985
Nature

Volume: 316, P: 748-750
Automated temporalis muscle quantification and growth charts for children through adulthood

Temporalis muscle thickness is a promising marker of lean muscle mass but has had limited utility due to its unknown normal growth trajectory and lack of standardized measurement. Here, the authors develop an automated deep learning pipeline to accurately measure temporalis muscle thickness from routine brain magnetic resonance imaging.

Anna Zapaishchykova
Kevin X. Liu
Benjamin H. Kann
ResearchOpen Access09 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well as cholesterol acquisition.

Andre Mu
William P. Klare
Mark J. Walker
ResearchOpen Access18 Mar 2023
Nature Communications

Volume: 14, P: 1-21
A high-throughput and low-waste viability assay for microbes

Using agar media suspended in pipette tips and a standard camera, the geometric viability assay provides a user-friendly and scalable update to standard colony-forming-unit-count approaches.

Christian T. Meyer
Grace K. Lynch
Joel M. Kralj
ResearchOpen Access02 Nov 2023
Nature Microbiology

Volume: 8, P: 2304-2314
Are nitrate levels in groundwater stable over time?

Perri Zeitz Ruckart
Alden K Henderson
W Dana Flanders
Research11 Apr 2007
Journal of Exposure Science & Environmental Epidemiology

Volume: 18, P: 129-133
Characterization of functional assays of multidrug resistance P-glycoprotein transport activity

I Bosch
CL Crankshaw
JM Croop
Research01 Jul 1997
Leukemia

Volume: 11, P: 1131-1137
Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture)

DM Livingston
W Kaelin
X Qin
Research01 Aug 1993
British Journal of Cancer

Volume: 68, P: 264-268
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

In a phase 2 trial, the oral type II RAF inhibitor tovorafenib exhibited an overall response rate of 67% in patients with BRAF-altered relapsed/refractory pediatric low-grade glioma.

Lindsay B. Kilburn
Dong-Anh Khuong-Quang
Karsten Nysom
ResearchOpen Access17 Nov 2023
Nature Medicine

Volume: 30, P: 207-217
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

Lindsay B. Kilburn
Dong-Anh Khuong-Quang
Karsten Nysom
Amendments and CorrectionsOpen Access16 Apr 2025
Nature Medicine

Volume: 31, P: 2454
A framework for human microbiome research

The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

Barbara A. Methé
Karen E. Nelson
Owen White
ResearchOpen Access13 Jun 2012
Nature

Volume: 486, P: 215-221
Regulation of adipogenesis and energy balance by PPARγ and PGC-1

BM Spiegelman
P Puigserver
Z Wu
Research01 Nov 2000
International Journal of Obesity

Volume: 24, P: S8-S10
Functional compensation precedes recovery of tissue mass following acute liver injury

The liver possesses the ability to regenerate following sudden injury. Here, the authors use single-cell RNA-sequencing and in situ transcriptional analyses to identify a new phase of liver regeneration in mice aimed at maintaining essential functions throughout the regenerative process.

Chad M. Walesky
Kellie E. Kolb
Wolfram Goessling
ResearchOpen Access19 Nov 2020
Nature Communications

Volume: 11, P: 1-12
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort

Michael S. Bloom
Sudhi Upadhyaya
Lynne M. Smith
ResearchOpen Access15 Feb 2025
Journal of Exposure Science & Environmental Epidemiology

Volume: 35, P: 992-1002
Differentiation and reversal of malignant changes in colon cancer through PPARγ

Pasha Sarraf
Elisabetta Mueller
Bruce M. Spiegelman
Research01 Sept 1998
Nature Medicine

Volume: 4, P: 1046-1052
Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli

Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks⁺ island develop a distinct mutational signature associated with colorectal cancer.

Cayetano Pleguezuelos-Manzano
Jens Puschhof
Hans Clevers
Research27 Feb 2020
Nature

Volume: 580, P: 269-273
Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

Curtis Huttenhower
Dirk Gevers
Owen White
ResearchOpen Access13 Jun 2012
Nature

Volume: 486, P: 207-214
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

Lindsay B. Kilburn
Dong-Anh Khuong-Quang
Karsten Nysom
Amendments and CorrectionsOpen Access11 Mar 2024
Nature Medicine

Volume: 30, P: 1500
Generation and Regulation of CD8⁺ Regulatory T Cells

Linrong Lu
Harvey Cantor
Reviews01 Dec 2008
Cellular & Molecular Immunology

Volume: 5, P: 401-406
MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells

J-J Lee
A Drakaki
K Struhl
Research28 Nov 2011
Oncogene

Volume: 31, P: 3818-3825
A new geodatabase of fuel treatments across federal lands in the USA

Anson Call
Nathan Tomczyk
Camille S. Stevens-Rumann
ResearchOpen Access26 Aug 2025
Scientific Data

Volume: 12, P: 1-12
Adipocyte differentiation from the inside out

Adipogenesis is a complex process that involves the integration of a network of signalling pathways and transcription factors. Elucidation of this network will help us understand the events that underlie adipocyte development, with implications for the growing burden of metabolic diseases.

Evan D. Rosen
Ormond A. MacDougald
Reviews01 Dec 2006
Nature Reviews Molecular Cell Biology

Volume: 7, P: 885-896
Prospects for combining targeted and conventional cancer therapy with immunotherapy

Insights into the effects of targeted therapies, conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical responses in patients.

Philip Gotwals
Scott Cameron
Glenn Dranoff
Reviews24 Mar 2017
Nature Reviews Cancer

Volume: 17, P: 286-301
Practice variation in therapeutic hypothermia for hypoxic ischemic encephalopathy among neonates with congenital heart disease in the United States

Vonita Chawla
Allison M. Peluso
Cherrie Welch
Research22 Nov 2024
Journal of Perinatology

Volume: 45, P: 265-267
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections22 May 2024
Nature Medicine

Volume: 30, P: 2091
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation

Katharina S. Appel
Chin Huang Lee
Jörg Janne Vehreschild
ResearchOpen Access13 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections14 Nov 2023
Nature Medicine

Volume: 30, P: 603
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections13 Dec 2023
Nature Medicine

Volume: 30, P: 605
The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

Thorsten Schmidt
Kathrin Körner
Tarik Möröy
Research29 Sept 1999
Cell Death & Differentiation

Volume: 6, P: 873-882
Disruption of differentiation in human cancer: AML shows the way

Daniel G. Tenen
Reviews01 Feb 2003
Nature Reviews Cancer

Volume: 3, P: 89-101
A joint international consensus statement for measuring quality of survival for patients with childhood cancer

The International Childhood Cancer Outcome Project group, involving survivors and other relevant stakeholders, develop a set of core outcomes to measure the quality of care for 17 types of childhood cancers.

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Reviews15 Jun 2023
Nature Medicine

Volume: 29, P: 1340-1348
Longitudinal analysis of the Five Sisters hot springs in Yellowstone National Park reveals a dynamic thermoalkaline environment

Jesse T. Peach
Rebecca C. Mueller
Brent M. Peyton
ResearchOpen Access04 Nov 2022
Scientific Reports

Volume: 12, P: 1-15
MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species

Elisabeth Roider
Alexandra I. T. Lakatos
David E. Fisher
ResearchOpen Access14 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Reporting guidelines for human microbiome research: the STORMS checklist

The STORMS tool provides guidance for concise and complete reporting of microbiome studies to facilitate manuscript preparation, peer review, reader comprehension of publications, and comparative analysis of published results.

Chloe Mirzayi
Audrey Renson
Levi Waldron
Reviews17 Nov 2021
Nature Medicine

Volume: 27, P: 1885-1892
Regulatory networks define phenotypic classes of human stem cell lines

Franz-Josef Müller
Louise C. Laurent
Jeanne F. Loring
Research24 Aug 2008
Nature

Volume: 455, P: 401-405
Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program

Frances A. Tylavsky
Assiamira Ferrara
Leonardo Trasande
Research24 Oct 2019
International Journal of Obesity

Volume: 44, P: 617-627

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