Nature Search

ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

In this work, the authors reveal that three non-ribosomal peptides targeting a common protein quality system differentially alter the Mycobacterium tuberculosis proteome, providing new insight into the molecular mechanisms behind their antimycobacterial activity.

Isabel K. Barter
Max J. Bedding
Richard J. Payne
ResearchOpen Access29 Jan 2026
Nature Communications

Volume: 17, P: 1-17
Gradient-based optimization of complex nanoparticle heterostructures enabled by deep learning on heterogeneous graphs

Graph neural networks built on physically motivated representations enable gradient-based optimization of complex upconverting nanoparticle heterostructures, revealing photophysical design rules and a roadmap for deep learning in nanoscience.

Eric Sivonxay
Lucas Attia
Samuel M. Blau
Research08 Dec 2025
Nature Computational Science

Volume: 6, P: 83-95
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

Jennifer Wessel
Audrey Y Chu
Mark O Goodarzi
ResearchOpen Access29 Jan 2015
Nature Communications

Volume: 6, P: 1-16
Observation of charge–parity symmetry breaking in baryon decays

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

R. Aaij
A. S. W. Abdelmotteleb
G. Zunica
ResearchOpen Access16 Jul 2025
Nature

Volume: 643, P: 1223-1228
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

Josée Dupuis
Claudia Langenberg
Inês Barroso
Research17 Jan 2010
Nature Genetics

Volume: 42, P: 105-116
Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows

An amplicon-based sequencing protocol that includes synthetic DNA spike-ins improves the quality and efficiency of SARS-CoV-2 high-throughput sequencing and detects common errors in genomic data.

Kim A. Lagerborg
Erica Normandin
Katherine J. Siddle
Research14 Dec 2021
Nature Microbiology

Volume: 7, P: 108-119
HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology

HDL-cholesterol levels in plasma predict the risk of cardiovascular disease, but a direct causal role for HDL in cardiovascular disease remains controversial. In this Review, Rosenson et al. discuss the opportunities afforded by an integrated approach that combines human genetic studies with systems biology to understand the complex metabolism of HDL and its potential atheroprotective properties.

Robert S. Rosenson
H. Bryan Brewer Jr
Robert A. Hegele
Reviews10 Aug 2017
Nature Reviews Cardiology

Volume: 15, P: 9-19
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josée Dupuis
Claudia Langenberg
Inês Barroso
Amendments and Corrections01 May 2010
Nature Genetics

Volume: 42, P: 464
Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5–CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data to refine the association at this locus.

Jason Z Liu
Federica Tozzi
Jonathan Marchini
Research25 Apr 2010
Nature Genetics

Volume: 42, P: 436-440

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ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

Gradient-based optimization of complex nanoparticle heterostructures enabled by deep learning on heterogeneous graphs

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Observation of charge–parity symmetry breaking in baryon decays

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows

HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

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