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Showing 1–5 of 5 results
Advanced filters: Author: Daniel J. D’Orazio Clear advanced filters

  • The amplitude and sinusoid-like shape of the optical variability of the light curve of PG 1302-102 is best fitted by relativistic Doppler boosting of emission from a compact, steadily accreting, unequal-mass binary, which is consistent with archival ultraviolet data, and suggests the existence of a binary black hole in the relativistic regime.

    • Daniel J. D'Orazio
    • Zoltán Haiman
    • David Schiminovich
    Research
    Nature
    Volume: 525, P: 351-353

  • Breakdown of the blood–brain barrier in individuals carrying the ε4 allele of the APOE gene, but not the ε3 allele, increases with and predicts cognitive impairment and is independent of amyloid β or tau pathology.

    • Axel Montagne
    • Daniel A. Nation
    • Berislav V. Zlokovic
    Research
    Nature
    Volume: 581, P: 71-76

  • Neuroimaging and cerebrospinal fluid analyses in humans reveal that loss of blood–brain barrier integrity and brain capillary pericyte damage are early biomarkers of cognitive impairment that occur independently of changes in amyloid-β and tau.

    • Daniel A. Nation
    • Melanie D. Sweeney
    • Berislav V. Zlokovic
    Research
    Nature Medicine
    Volume: 25, P: 270-276

  • Individuals with the red hair/fair skin phenotype usually carry a polymorphism in the gene encoding the melanocortin 1 receptor (Mc1r) that results in the production of pigment containing a high pheomelanin-to-eumelanin ratio; here it is shown in a mouse model that inactivation of Mc1r promotes melanoma formation in the presence of the Braf oncogene, thus suggesting that pheomelanin synthesis is carcinogenic by an ultraviolet-radiation-independent mechanism.

    • Devarati Mitra
    • Xi Luo
    • David E. Fisher
    Research
    Nature
    Volume: 491, P: 449-453