Nature Search

Investigating the analytical robustness of the social and behavioural sciences

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Balazs Aczel
Barnabas Szaszi
Brian A. Nosek
Research01 Apr 2026
Nature

Volume: 652, P: 135-142
Reproducibility and robustness of economics and political science research

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Abel Brodeur
Derek Mikola
Yaolang Zhong
Research01 Apr 2026
Nature

Volume: 652, P: 151-156
Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial

KRAS mutations are keenly associated with pancreatic ductal adenocarcinoma and represent a potential therapeutic target. Here the authors present the findings from a phase I clinical trial testing pooled KRAS mutant peptides in combination with immune checkpoint blockade in patients with resected pancreatic ductal adenocarcinoma.

Amanda L. Huff
S. Daniel Haldar
Neeha Zaidi
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-18
Chain Initiation by Reovirus RNA Transcriptase in vitro

DANIEL H. LEVIN
GEORGE ACS
SAMUEL C. SILVEBSTEIN
Research08 Aug 1970
Nature

Volume: 227, P: 603-604
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Multi-ancestry genome-wide and transcriptome-wide association studies of aortic stenosis identify more than 200 independent risk loci and provide insights into its genetic architecture.

Aeron M. Small
Ta-Yu Yang
George Thanassoulis
ResearchOpen Access19 Dec 2025
Nature Genetics

Volume: 58, P: 57-66
Restoring rapid natural bimanual typing with a neuroprosthesis after paralysis

Jude et al. present a communication intracortical brain–computer interface typing neuroprosthesis enabling familiar, high-speed, bimanual QWERTY keyboard functionality for people with paralysis through the decoding of attempted finger movements.

Justin J. Jude
Hadar Levi-Aharoni
Daniel B. Rubin
ResearchOpen Access16 Mar 2026
Nature Neuroscience

P: 1-10
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

François Conquet
Zafar I. Bashir
Francis Crépel
Research17 Nov 1994
Nature

Volume: 372, P: 237-243
136 ADMINISTRATION OF INDOMETHACIN TO THE PREGNANT EWE RESULTS IN CONSTRICTION OF THE FETAL DUCTUS ARTERIOSUS

Daniel L Levin
Lawrence J Mills
James Garriott
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 386
Antibodies to a scrapie prion protein

Paul E. Bendheim
Ronald A. Barry
Stanley B. Prusiner
Research02 Aug 1984
Nature

Volume: 310, P: 418-421
Noise in human muscle spindles

Paul Cordo
J. Timothy Inglis
Frank Moss
Research31 Oct 1996
Nature

Volume: 383, P: 769-770
Abolition of actin-bundling by phosphorylation of human erythrocyte protein 4.9

Athar Husain-Chishti
Andrew Levin
Daniel Branton
Research01 Aug 1988
Nature

Volume: 334, P: 718-721
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy

Genome-wide analysis in individuals of African ancestry identifies a nonsense variant in CD36 associated with increased risk of dilated cardiomyopathy (DCM), partly accounting for the higher incidence of DCM in African-ancestry populations.

Jennifer E. Huffman
Liam Gaziano
Krishna G. Aragam
ResearchOpen Access31 Oct 2025
Nature Genetics

Volume: 57, P: 2682-2690
Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

Patricia L. Tavormina
Rita Shiang
John J. Wasmuth
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 321-328
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

Steven A. Kliewer
Kazuhiko Umesono
Ronald M. Evans
Research27 Aug 1992
Nature

Volume: 358, P: 771-774
Author Correction: Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum

David S. M. Lee
Kathleen M. Cardone
Scott M. Damrauer
Amendments and Corrections28 Nov 2025
Nature Genetics

Volume: 57, P: 3201
Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

Duncan McVey
Leonardo Brizuela
David Beach
Research12 Oct 1989
Nature

Volume: 341, P: 503-507
Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

Joel B. Nelson
Sean P. Hedican
Jonathan W. Simons
Research01 Sept 1995
Nature Medicine

Volume: 1, P: 944-949
Dominant mutations in the type II collagen gene, COL2A1, produce spondyloepimetaphyseal dysplasia, Strudwick type

George E. Tiller
Paula A. Polumbo
David R. Eyre
Research01 Sept 1995
Nature Genetics

Volume: 11, P: 87-89
A neural basis for lexical retrieval

Hanna Damasio
Thomas J. Grabowski
Antonio R. Damasio
Research11 Apr 1996
Nature

Volume: 380, P: 499-505
Bimodality and alternative equilibria do not help explain long-term patterns in shallow lake chlorophyll-a

Shallow lakes have long been considered an example of alternative equilibria in ecological systems. Here, the authors combine empirical data and simulations to show that the relationship of shallow lake chlorophyll-a with nutrient enrichment does not fit the theory of alternative stable states.

Thomas A. Davidson
Carl D. Sayer
Daniel Graeber
ResearchOpen Access25 Jan 2023
Nature Communications

Volume: 14, P: 1-11
Quantitative evaluation of concanavalin A receptor site distributions on the surfaces of specific populations of embryonic cells

ANTHONY NERI
MARIE ROBERSON
STEVEN B. OPPENHEIMER
Research27 Nov 1975
Nature

Volume: 258, P: 342-344
Multidimensional specialization and generalization are pervasive in soil prokaryotes

Analyses of soil microbiomes across the United States reveal pervasive multidimensional specialization and generalization across prokaryotic communities impacting evolutionary trajectories, microbial dominance and community roles.

Damian J. Hernandez
Kasey N. Kiesewetter
Michelle E. Afkhami
Research07 Aug 2023
Nature Ecology & Evolution

Volume: 7, P: 1408-1418
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum

Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across the allele-frequency spectrum.

David S. M. Lee
Kathleen M. Cardone
Scott M. Damrauer
Research07 Apr 2025
Nature Genetics

Volume: 57, P: 829-838
The serpin PAI-1 inhibits cell migration by blocking integrin α_vβ₃ binding to vitronectin

Steingrimur Stefansson
Daniel A. Lawrence
Research03 Oct 1996
Nature

Volume: 383, P: 441-443
A copia-like transposable element family in Arabidopsis thaliana

Daniel F. Voytas
Frederick M. Ausubel
Research01 Nov 1988
Nature

Volume: 336, P: 242-244
Female infertility in mice lacking connexin 37

Alexander M. Simon
Daniel A. Goodenough
David L. Paul
Research06 Feb 1997
Nature

Volume: 385, P: 525-529
A potent cyclic hexapeptide analogue of somatostatin

Daniel F. Veber
Roger M. Freidinger
Ralph Hirschmann
Research02 Jul 1981
Nature

Volume: 292, P: 55-58
Prediction of the structure of a receptor–protein complex using a binary docking method

Barry L. Stoddard
Daniel E. Koshland Jr
Research27 Aug 1992
Nature

Volume: 358, P: 774-776
Drug–Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice

CD388 is a first-in-class antiviral drug–Fc conjugate engineered for extended half-life that demonstrates potent prophylactic and therapeutic efficacy against lethal influenza A and B challenge in mice.

Simon Döhrmann
James Levin
Leslie W. Tari
ResearchOpen Access17 Mar 2025
Nature Microbiology

Volume: 10, P: 912-926
Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene

Andrea Superti-Furga
Johanna Hästbacka
Richard Gitzelmann
Research01 Jan 1996
Nature Genetics

Volume: 12, P: 100-102
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

Single-nucleus RNA sequencing of human visceral and subcutaneous adipose tissues is used to identify adipocyte subpopulations and explore their developmental trajectories and interactions.

Or Lazarescu
Maya Ziv-Agam
Esti Yeger-Lotem
ResearchOpen Access24 Jan 2025
Nature Genetics

Volume: 57, P: 413-426
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

Roberta Montes de Oca Luna
Daniel S. Wagner
Guillermina Lozano
Research09 Nov 1995
Nature

Volume: 378, P: 203-206
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Madhurima Chatterjee
Selcuk Özdemir
Anja Schneider
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 1771-1783
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Richard Karlsson Linnér
Pietro Biroli
Jonathan P. Beauchamp
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 245-257
A shared alarmone–GTP switch controls persister formation in bacteria

Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.

Danny K. Fung
Jessica T. Barra
Jue D. Wang
ResearchOpen Access15 May 2025
Nature Microbiology

Volume: 10, P: 1617-1629
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Memories of nicotine

Daniel S. McGehee
Lorna W. Role
News & Views24 Oct 1996
Nature

Volume: 383, P: 670-671
Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease

By conducting a large multi-ancestry GWAS of varicose veins followed by bioinformatics analyses, Levin et al. identified new and recurrent causal variants, traits with shared genetic mechanisms, and putative causal risk factors of the disease, revealing its polygenic architecture and genetic overlap with arterial and venous disease and identifying potential therapeutic targets.

Michael G. Levin
Jennifer E. Huffman
Scott M. Damrauer
Research09 Jan 2023
Nature Cardiovascular Research

Volume: 2, P: 44-57
Disruption of trait-environment relationships in African megafauna occurred in the middle Pleistocene

Mammalian megafaunal biodiversity has declined since the Plio-Pleistocene. Here, the authors apply ecometric methods to evaluate the functional link between eastern African herbivorous megafauna and their environments, showing that some biodiversity loss coincided with community ecological function disturbance.

Daniel A. Lauer
A. Michelle Lawing
Jenny L. McGuire
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-15
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons

Toxoplasma gondii secretion systems can be engineered to deliver multiple large therapeutic proteins to neurons in vitro and in vivo.

Shahar Bracha
Hannah J. Johnson
Oded Rechavi
ResearchOpen Access29 Jul 2024
Nature Microbiology

Volume: 9, P: 2051-2072
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

Stephan Heckers
Scott Rauch
Nathaniel Alpert
Research01 Aug 1998
Nature Neuroscience

Volume: 1, P: 318-323
Community crystal gazing

A selection of individuals from the biotech ecosystem give their views on the challenges facing the sector over the coming years.

Anu Acharya
Kate Bingham
Daphne Zohar
Special Features10 Mar 2016
Nature Biotechnology

Volume: 34, P: 276-283
Nucleotide exchange is sufficient for Hsp90 functions in vivo

A complete understanding of the role of ATP hydrolysis in Hsp90 function is elusive. Here, the authors show that ATP hydrolysis, but not binding, is dispensable for essential or specialized Hsp90 functions in vivo, shedding new light on this mystery.

Michael Reidy
Kevin Garzillo
Daniel C. Masison
ResearchOpen Access29 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Genome-wide association meta-analysis of AAA identifies 121 independent risk loci and highlights potential therapeutic targets such as proprotein convertase, subtilisin/kexin-type 9 (PCSK9).

Tanmoy Roychowdhury
Derek Klarin
Scott M. Damrauer
ResearchOpen Access16 Oct 2023
Nature Genetics

Volume: 55, P: 1831-1842
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Cell-specific targeting of Sindbis virus vectors displaying IgG-binding domains of protein A

Kouichi Ohno
Keisuke Sawai
Daniel Meruelo
Research01 Aug 1997
Nature Biotechnology

Volume: 15, P: 763-767
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

Julie Gonneaud
Alex T. Baria
Etienne Vachon-Presseau
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Pancytopenia in Propionic Acidemia: Hematologic Evaluation and Studies of Hematopoiesis in Vitro

Linda C Stork
Daniel R Ambruso
Edward R B McCabe
Research01 Aug 1986
Pediatric Research

Volume: 20, P: 783-788
A new, rare, small-ranged, and endangered mountain snake of the genus Elaphe from the Southern Levant

Daniel Jablonski
Marco Antônio Ribeiro-Júnior
Shai Meiri
ResearchOpen Access24 Mar 2023
Scientific Reports

Volume: 13, P: 1-24

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