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Showing 1–26 of 26 results
Advanced filters: Author: Daniel T. Gilliam Clear advanced filters

  • It remains unclear how opponent serotonin and dopamine signals regulate striatal activity to exert opposing effects on behavior. This study reveals how the complement of serotonin and dopamine receptors expressed by cells in the striatum enable the two neuromodulators to exert opposing functions during reward learning.

    • Daniel F. Cardozo Pinto
    • Michaela Y. Guo
    • Robert C. Malenka
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • A neuron-specific activity-dependent DNA repair mechanism is identified, the impairment of which may lead to neurodevelopmental disorders, neurodegeneration and ageing.

    • Elizabeth A. Pollina
    • Daniel T. Gilliam
    • Michael E. Greenberg
    ResearchOpen Access
    Nature
    Volume: 614, P: 732-741

  • How microbial community properties change under increasingly complex combinations of resources remains unclear. Here, the authors studied hundreds of synthetic consortia to identify the factors that govern how growth and taxonomic diversity scale with environmental complexity.

    • Alan R. Pacheco
    • Melisa L. Osborne
    • Daniel Segrè
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.

    • Colin J. Mann
    • Pan Yang
    • Jonathan Abraham
    ResearchOpen Access
    Nature Microbiology
    Volume: 10, P: 2207-2220

  • Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

    • Debora L. Gisch
    • Michelle Brennan
    • Michael T. Eadon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The study demonstrates that specific recognition and custom binding geometries can be computationally encoded between protein spans within lipids through designing synthetic transmembrane proteins to functionally regulate a target cytokine receptor.

    • Marco Mravic
    • Li He
    • William F. DeGrado
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 751-760

  • A substrate-guided design strategy generated highly potent inhibitors of the biosynthesis of the genotoxin colibactin by human gut bacteria. These inhibitors also enable a generalizable approach for chemically guided natural product discovery.

    • Matthew R. Volpe
    • José A. Velilla
    • Emily P. Balskus
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 159-167

  • A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • Rajasree Menon
    • Sanjay Jain
    ResearchOpen Access
    Nature
    Volume: 619, P: 585-594

  • A double-transgenic mouse model that enables monitoring or manipulation of dopamine and serotonin simultaneously in the brain’s nucleus accumbens shows that these neuromodulators have opponent roles in reward learning.

    • Daniel F. Cardozo Pinto
    • Matthew B. Pomrenze
    • Robert C. Malenka
    Research
    Nature
    Volume: 639, P: 143-152

  • Although structural variation has been previously associated with autism spectrum disorders, this study reports a genome-wide significant association of common variants with susceptibility to this disorder group. The results implicate neuronal cell-adhesion molecules in the pathogenesis of this group of neurodevelopmental and neuropsychiatric disorders.

    • Kai Wang
    • Haitao Zhang
    • Hakon Hakonarson
    Research
    Nature
    Volume: 459, P: 528-533

  • Here, the authors perform a large-scale, high-throughput biochemical assay to determine the compatibility of over 300,000 domain recombination variants of the inward rectifier K+ channel Kir2.1. They derive rules for designing domain insertion variants that fold and traffic to the cell surface and conclude that the insertion of domains at protein termini is evolutionary favoured.

    • Willow Coyote-Maestas
    • David Nedrud
    • Daniel Schmidt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Polarisation of epithelial cells causes lumen formation, which is mediated by apical membrane initiation site (AMIS) and FIP5, but how this is regulated is unclear. Here, the authors identify cingulin as a FIP-5 interacting protein, recruiting the Rac1-WAVE/Scar complex to the AMIS and branched actin formation.

    • Anthony J. Mangan
    • Daniel V. Sietsema
    • Rytis Prekeris
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • In considering cross-feeding among microbes within communities, it is typically assumed that metabolic secretions are costly to produce. However, Pacheco et al. use metabolic models to show that ‘costless’ secretions could be common in some environments and important for structuring interactions among microbes.

    • Alan R. Pacheco
    • Mauricio Moel
    • Daniel Segrè
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

    • Lauren A. Weiss
    • Dan E. Arking
    • Leena Peltonen
    Research
    Nature
    Volume: 461, P: 802-808

  • Rett syndrome is caused by mutation of the MECP2 gene that codes for a protein that binds methylated DNA; this study reveals that MeCP2 affects the expression of long genes, which often serve neuronal functions.

    • Harrison W. Gabel
    • Benyam Kinde
    • Michael E. Greenberg
    Research
    Nature
    Volume: 522, P: 89-93

  • Examination of the ecosystem properties of treeline ecotones in seven temperate regions of the world shows that the reduction in temperature with increasing elevation does not affect tree leaf nutrient concentrations, but does reduce ground-layer community-weighted plant nitrogen levels, leading to a strong stoichiometric convergence of ground-layer plant community nitrogen to phosphorus ratios across all regions.

    • Jordan R. Mayor
    • Nathan J. Sanders
    • David A. Wardle
    Research
    Nature
    Volume: 542, P: 91-95