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Showing 1–11 of 11 results
Advanced filters: Author: Dany Anglicheau Clear advanced filters

  • Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.

    • Baptiste Lamarthée
    • Armance Marchal
    • Julien Zuber
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Kidney transplants are at risk of graft failure due to immune system rejection. Here, the authors assess a broad range of clinical and immunological baseline variables in a large, unselected kidney transplant cohort, providing further insights into factors associated with antibody-mediated rejection

    • Zeynep Demir
    • Marc Raynaud
    • Alexandre Loupy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Proteinuria is a known marker of poor prognosis in kidney transplant recipients. A recent study by Amer et al. brings further insights to this topic by investigating whether the composition of proteinuria affects outcomes.

    • Christophe Legendre
    • Dany Anglicheau
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 251-252

  • A prospective observational study including 2,882 kidney allograft recipients from 14 transplantation centers in Europe and the United States shows that cell-free DNA can be used to detect kidney allograft rejection.

    • Olivier Aubert
    • Cindy Ursule-Dufait
    • Alexandre Loupy
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2320-2327

  • Fibroblast heterogeneity is a recognized feature in chronic kidney disease, and although fibrosis is integrant to the pathology, it is lesser known which of the fibroblast populations contribute. Here authors describe a population of proinflammatory fibroblasts, which are found in close proximity to macrophages and may facilitate their recruitment and acquisition of a FOLR2+, pathogenic phenotype.

    • Camille Cohen
    • Rana Mhaidly
    • Fatima Mechta-Grigoriou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • Analysis of a multicenter cohort of kidney transplants shows that mismatches in the MICA locus and the presence of anti-MICA donor-specific antibodies are associated with reduced graft survival and increased rejection.

    • Raphael Carapito
    • Ismail Aouadi
    • Seiamak Bahram
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 989-998

  • Although long-term kidney allograft failure is broadly classified as T cell- or antibody-mediated, this dichotomy is not always apparent in all patients, highlighting the need for improved allograft tissue characterisation. Here, the authors use single-cell RNA sequencing and multiplex imaging for transcriptomic and spatial profiling of allograft tissue from patients experiencing different degrees of rejection severity.

    • Baptiste Lamarthée
    • Jasper Callemeyn
    • Maarten Naesens
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • In this Review, the authors provide an overview of the roles of miRNAs in the development of chronic kidney disease, acute kidney injury and allograft injury. They also discuss the utilization of miRNAs as biomarkers and their potential as therapeutic targets in kidney disease.

    • Nassim Mahtal
    • Olivia Lenoir
    • Pierre-Louis Tharaux
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 643-662