Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–16 of 16 results
Advanced filters: Author: Daohua Chen Clear advanced filters

  • Riboflavin is an essential vitamin for humans. Here, authors present cryo-EM structures of human riboflavin transporter RFVT2/RFVT3, revealing the structural basis for riboflavin transport and defining the determinant for pH-dependent activity of RFVT3.

    • Ke Wang
    • Huiwen Chen
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Fan et al. report a potent and subtype-selective TRPV3 antagonist, Trpvicin, and reveal its binding sites and mode of action for TRPV3 inhibition via high-resolution cryogenic electron microscopy structures.

    • Junping Fan
    • Linghan Hu
    • Xiaoguang Lei
    Research
    Nature Chemical Biology
    Volume: 19, P: 81-90

  • Inactivation is an intrinsic property of NaV channel, but the mechanism for slow inactivation is not fully understood. Here, authors show a NaVEh structure in a potential slow-inactivated state, elucidating structural basis for slow inactivation.

    • Huiwen Chen
    • Zhanyi Xia
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Cryo-electron microscopy structures of human XPR1 in different bound forms reveal the structural basis for XPR1 gating and regulation by inositol polyphosphates.

    • Rui Yan
    • Huiwen Chen
    • Daohua Jiang
    Research
    Nature
    Volume: 633, P: 960-967

  • Voltage-gated sodium channels mediate electrical signaling. Here, authors report the cryo-EM structure of NaVEh from the marine plant Emiliania huxleyi, revealing an unexpected mechanism of N-type fast inactivation.

    • Jiangtao Zhang
    • Yiqiang Shi
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Structures of human vesicular monoamine transporter 2 in complexes with serotonin and three clinical drugs provide insights into the structural basis for serotonin transport and inhibition of transporter activity by the drugs.

    • Di Wu
    • Qihao Chen
    • Daohua Jiang
    Research
    Nature
    Volume: 626, P: 427-434

  • In C. elegans, systemic RNAi is initiated by SID-1-mediated dsRNA internalization. Here the authors present cryo-EM structures of SID-1 homologs and the SID-1–dsRNA complex, elucidating the structural basis for dsRNA recognition and uptake by SID-1.

    • Jiangtao Zhang
    • Chunhua Zhan
    • Daohua Jiang
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1095-1104

  • Here the authors show structures of the vesicular acetylcholine transporter in its apo state and in complex with the substrate acetylcholine and the inhibitor vesamicol, providing insights into substrate recognition, proton coupling and conformational transition mechanisms.

    • Qiao Ma
    • Kunpeng Ma
    • Yan Zhao
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 818-827

  • The voltage-gated sodium channel NaV1.7 plays essential roles in pain sensation. The authors report cryo-EM structures of NaV1.7 in complexes with three pore blockers, elucidating distinct mechanisms of action of their modulation on NaV1.7.

    • Jiangtao Zhang
    • Yiqiang Shi
    • Daohua Jiang
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1208-1216