Nature Search

Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate

Nguyen et al. show that the splenic environment provides sequential signals via lymphotoxin and retinoic acid that guide cDC2A development and retention.

Albert A. Nguyen
Logan Fisher
Chrysothemis C. Brown
Research21 Nov 2025
Nature Immunology

Volume: 26, P: 2159-2169
Molecular basis of foreign DNA recognition by BREX anti-phage immunity system

BrxX methylase in complex with SAM cofactor mediates foreign DNA recognition by the BREX system. BrxX can be engineered to modify BREX specificity and enhance defense. BREX defense and methylation require assembly of supramolecular BrxBCXZ complex.

Alena Drobiazko
Myfanwy C. Adams
Artem Isaev
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape

Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and depolymerize microtubule plus-ends. This study shows how kinesin-8s alternate between a promotility and a pro-microtubule-depolymerization state via their tubulin shape-sensing loop-2 region.

Byron Hunter
Matthieu P. M. H. Benoit
John S. Allingham
ResearchOpen Access20 Jul 2022
Nature Communications

Volume: 13, P: 1-19
Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate

The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.

Daria Trofimova
Mohammadjavad Paydar
John S. Allingham
ResearchOpen Access06 Jul 2018
Nature Communications

Volume: 9, P: 1-13
Ste2 receptor-mediated chemotropism of Fusarium graminearum contributes to its pathogenicity against wheat

Pooja S. Sridhar
Daria Trofimova
Michele C. Loewen
ResearchOpen Access01 Jul 2020
Scientific Reports

Volume: 10, P: 1-15

Quick links

Search

Filter By:

Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate

Molecular basis of foreign DNA recognition by BREX anti-phage immunity system

Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape

Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate

Ste2 receptor-mediated chemotropism of Fusarium graminearum contributes to its pathogenicity against wheat

Search

Quick links