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Colloidal suspensions often contain mixtures of particles that must be sorted by size or density, but the sediment structure resulting from polydisperse particles settling rapidly remains unclear. Bidisperse colloids with soft-sphere interactions are now shown to spontaneously arrange into two macroscopic layers after sedimentation.

Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors.

Ferroelectric materials are characterized by a spontaneous polarization, which in practical applications is manipulated by an electric field. This study examines how defects affect the switching with atomic resolution, by usingin situaberration-corrected transmission electron microscopy.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

An amphiphilic mimotope vaccine can be used in tandem with Food and Drug Administration (FDA)-approved CD19 CAR-T cell products.

Sleep rearranges the firing patterns of excitatory projection neurons in zebra finch songbirds. Patterned inhibition is implicated in maintaining stable songs in spite of the instability in the projection neuron population.

A global dataset of the satellite-tracked movements of pelagic sharks and fishing fleets show that sharks—and, in particular, commercially important species—have limited spatial refuge from fishing effort.

Panzeri et al. use a Trim28^+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, linked to a relevant DNA hypomethylation signature.

EDI048 is a gastrointestinal-targeted Cryptosporidium PI(4)K inhibitor that undergoes a predictable metabolism and limits systemic exposure without compromising its anti-parasitic activity.

Here the authors investigate lipid nanodiscs as drug carriers for antitumour immunotherapy. They demonstrate that flexible lipid nanodiscs functionalized with STING-activating cyclic dinucleotides exhibit superior tumour penetration and tumour cell uptake compared with spherical liposomes, resulting in improved antitumour T-cell priming and tumour regression.

The climate of the northwest Atlantic shifts between phases, shaping ecosystem productivity and fisheries. Tracking these phases can support climate and ecosystem-informed fisheries management.

A large outbreak of shigellosis occurred in Albuquerque, New Mexico in 2021–2023 and affected non-human primates at a local zoo as well as humans. Here, the authors describe the outbreak investigation and demonstrate that cases in non-human primates were caused by the same strain of Shigella flexneri as those causing human cases.

Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predict the development of kidney failure.

Yang et al. show that neuronatin (NNAT) can explain part of the phenotypic variation of complex traits, independently of genetics or the environment. Such NNAT-dependent variations can stratify human cohorts into four metabolic sub-types, including two distinct types of obesity.

Electric fields typically break symmetry when applied as a stimulus to materials. Here, by forming a superlattice of BiFeO₃ and TbScO₃, it is shown that an electric field can repeatedly stabilize mixed-phase polar and antipolar BiFeO₃.

The striped polarization domains in a BiFeO₃/TbScO₃ heterostructure induce alternating p- and n-type doping at the interface, giving rise to strongly anisotropic in-plane conductance.

Kathiriya et al. report that fibrotic signalling in the lung mesenchyme leads to transdifferentiation of human alveolar type 2 cells into KRT5⁺ basal cells, providing a mechanistic explanation for the pathology associated with severe lung injuries.

Neurons in the basolateral amygdala show increased response to conditioned stimuli predicting rewards. Here the authors show that their activity is not correlated with the reward-predicting stimulus but rather with the conditioned behaviour.

Jacks and colleagues demonstrate the effects of neoantigen expression level on T-cell priming and immune surveillance during tumor development and progression and explore implications for immunotherapies, using in vivo models of colorectal cancer.

Neurons in the canary premotor cortex homologue encode past song phrases and transitions, carrying information relevant to future choice of phrases as ‘hidden states’ during song.

The immunogen RC1 facilitates recognition of the V3-glycan patch on the envelope of HIV-1 and elicits specific serological responses in mice and macaques, making it a possible priming immunogen for sequential vaccination strategies in humans.

A study of more than 1000 paleoclimate datasets reveals that the ”4.2 ka event” is not a globally significant climate excursion, unlike the prominent 8.2 ka event. In the Holocene, site-level excursions are common, but global-scale events are rare.

Cytokine therapies have been used to treat cancer but are susceptible to adverse effects owing to the activation of systemic inflammatory pathways. Here the authors avoid this toxicity by developing CD45-targeted IL-12 and IL-15 immunocytokines that are effective in treating tumors in mice when dosed intratumorally.

The intratumoural injection of recombinantly expressed cytokines bound tightly to the common vaccine adjuvant aluminium hydroxide leads to weeks-long retention of the cytokines in the tumours with minimal side effects, as shown in multiple syngeneic mouse models.

Competing phases in layered complex oxides are believed to be relevant for emergent phenomena, which still await to be witnessed. Here, Stone et al. report direct atomic-scale imaging of a multitude of polar phases in Ruddlesden-Popper oxide thin films, exhibiting diverse phenomena in a single structure.

Mota et al. show that poor response to immune checkpoint blockade in mouse models of ALK-rearranged NSCLC can be overcome by vaccination with an immunogenic ALK peptide and identify immunogenic human ALK peptides for future translational study.

This protocol presents a method for the preparation and culture of mouse and human primary or pluripotent stem cell-derived basal cells, followed by their intra-airway transplantation into polidocanol-conditioned mice to achieve in vivo airway regeneration.

Authors apply atom probe tomography to image and quantify the 3D distribution of oxygen vacancies in (LuFeO₃)₉/(LuFe₂O₄)₁ superlattices, linking local variations in chemical composition to the emergent multiferroic properties.

Many important cellular structures in the body are curved at the scale of multiple cell lengths. Cells respond collectively to this curvature, and it influences their migration during development and growth.

During a photoinduced phase transition, electronic rearrangements are usually faster than lattice ones. Time-resolved measurements now show that the insulator-to-metal transition in a thin-film Mott insulator is preceded by lattice reconfiguration.

Human respiratory bronchioles contain a unique population of secretory cells called respiratory airway secretory cells that are distinct from the cells in the larger proximal airways, and act as unidirectional progenitors for alveolar type 2 cells.

The electronic interactions at the interface of oxide materials promise properties that can be very different from those of the parent compounds. The finding that many-body interactions in oxide superlattices can be used to engineer electronic properties offers a new strategy for designing oxide heterostructures.

Alum coupled to protein immunogens via site-specific phosphoserine-containing linkers enhances long-lived B cell responses and can selectively direct antibodies toward protective neutralizing epitopes.

Treatment of patients with relapsed or refractory multiple myeloma with a combination of the BCMA-targeting antibody–drug conjugate belatamab mafodotin with dexamethasone and pomlidomide is safe and shows promising preliminary clinical efficacy.

T cells with a chimaeric antigen receptor specific for fluorescein isothiocyanate can be directed against solid tumours via the intratumoural administration of a fluorescein isothiocyanate-conjugated amphiphile that inserts itself in cell membranes.

Existing single-cell RNA-seq methods provide the transcriptome of a cellular phenotype at a single time point. Here, Kimmerlinget al. present a microfluidic platform that enables off-chip single-cell RNA-seq after multigenerational lineage tracking under controlled culture conditions.

Clostridium difficile infection (CDI) is a common complication of IBD and is associated with disease flare-ups and adverse outcomes. Low levels of serum albumin and haemoglobin alongside high concentrations of serum creatinine predict the need for surgery and risk of death associated with CDI in patients with IBD.

A universal mechanical exfoliation method of creating freestanding membranes of complex-oxide materials with different crystal structures and orientations and stacking them to produce a range of artificial heterostructures with hybridized physical properties is described.

State-of-the-art electron energy-loss spectroscopy in a transmission electron microscope maps the detailed phonon spectra of single defects in silicon carbide

A computational algorithm integrates lineage tracing with single-cell RNA sequencing and improves early cell fate prediction.

Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness that associates with worse clinical outcomes.