The cellular mechanisms to initiate allergic responses involve various immune cells in the lungs. Here the authors identify a Ly6G+Nur77+ macrophage population involved in initiation of HDM-driven Th2 responses that detect Derp1 allergen through PAR2 and modulate migration of conventional DC to draining lymph nodes via cysteinyl leukotriene production.
- Audrey Meloun
- Holly Bachus
- Beatriz León
