Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: David Bednar Clear advanced filters

  • The identification of aggregation-prone regions in proteins and their suppression through mutations is a powerful strategy to enhance protein solubility and yield, expanding their potential applications. Here, the authors identify miss-annotations on widespread aggregation databases and apply a deep neural network-based predictor that generates a residue-level aggregation profile for protein sequences (AggreProt) to identify aggregation-prone regions in the LinB enzyme and design mutations to suppress aggregation in its exposed regions.

    • Vojtech Cima
    • Antonin Kunka
    • Jan Martinovic
    ResearchOpen Access
    Communications Chemistry
    P: 1-13

  • Merging carbonyls to form an alkene by removing their oxygens is rare, yet synthetically useful, and the selective combination of two different carbonyls is especially challenging. Now, two strategies for cross-metathesis of unbiased carbonyls have been developed. An Fe-catalysed carbene/ylide strategy affords Z-alkenes, while Cr-catalysed gem-di-metals yield E-alkenes.

    • Lumin Zhang
    • David A. Nagib
    Research
    Nature Chemistry
    Volume: 16, P: 107-113

  • NanoLuc luciferase is a popular bioluminescent enzyme, but the molecular details of its mechanism of action on luciferins such as coelenterazine remained elusive. Here the authors use, protein crystal structures and biochemical analyses to provide an atomistic description of its catalytic mechanism and allosteric behaviour.

    • Michal Nemergut
    • Daniel Pluskal
    • Martin Marek
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Renilla luciferase is a popular bioluminescent enzyme, but the molecular details of its mechanism of action on luciferins such as coelenterazine remained elusive. Now, protein crystal structures and biochemical analyses provide an atomistic description of its catalytic mechanism.

    • Andrea Schenkmayerova
    • Martin Toul
    • Martin Marek
    Research
    Nature Catalysis
    Volume: 6, P: 23-38

  • Directed evolution commonly relies on point mutations but InDels frequently occur in evolution. Here the authors report a protein-engineering framework based on InDel mutagenesis and fragment transplantation resulting in greater catalysis and longer glow-type bioluminescence of the ancestral luciferase.

    • Andrea Schenkmayerova
    • Gaspar P. Pinto
    • Jiri Damborsky
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Radical-mediated functionalization streamlines access to complex synthetic targets. Now, a sulfonium-based donor–acceptor pair enables photoinduced charge-transfer interactions to access electronically diverse aryl radicals. Reaction with enol ethers or isocyanide provides a metal-free method for arene functionalization.

    • Taylor N. Bednar
    • David A. Nagib
    News & Views
    Nature Chemistry
    Volume: 15, P: 3-4

  • Heatwaves are becoming increasingly frequent and more intense, causing severe economic impacts through reduced labour productivity. Here, the authors show that economic damages in Europe exceed 1% of the GDP in vulnerable areas, which might increase by a factor of almost five in the medium term without climate action.

    • David García-León
    • Ana Casanueva
    • Lars Nybo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Quantum computing is a promising technology to solve complex challenges that would take classical computers an impractical amount of time. This Perspective discusses the current state of quantum computing and possible applications in enzyme engineering and biocatalysis.

    • Jiri Damborsky
    • Petr Kouba
    • Stanislav Mazurenko
    Reviews
    Nature Catalysis
    Volume: 8, P: 872-880

  • Despite increased attention, residential energy insecurity is a widespread and persistent problem in the USA. We commend ongoing investigations, urge scholars to continue to examine why some households disproportionately experience energy insecurity, and offer several lines of inquiry that may help reduce energy insecurity’s incidence and impact.

    • Michelle Graff
    • Sanya Carley
    • Trevor Memmott
    Comments & Opinion
    Nature Energy
    Volume: 8, P: 550-553