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Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.

A semiconductor chip, coupled to an ion-sensitive field effect transistor (ISFET) pH sensor, can amplify and quantitate DNA in real time without dyes, cameras and external heating devices.

Cryptococcal meningitis is a common infection in patients with compromised CD4 T cell function. Using a CD4 T cell activation tracking mouse the authors show the localisation and activation of CD4 T cells in the brain after cryptococcus infection and how these cells interact with MHCII expressing microglia which may increase pathologic brain inflammation.

High-fidelity deterministic quantum state transfer and multi-qubit entanglement are demonstrated in a quantum network comprising two superconducting quantum nodes one metre apart, with each node including three interconnected qubits.

The creation of artificial metalloenzymes compatible with complex biological settings could enable broad applications. Now a de novo-designed artificial metalloenzyme containing an abiological ruthenium cofactor is reported and optimized for ring-closing metathesis in the cytoplasm of whole cells.

A minimal artificial Kitaev chain can be realized by using two spin-polarized quantum dots in an InSb nanowire strongly coupled by both elastic co-tunnelling and crossed Andreev reflection.

The role of the dielectric environment in thermally activated delayed fluorescence (TADF) is not yet fully understood. Here the authors reveal the relevance of environment–emitter interactions in gating the reverse intersystem crossing and its particular relevance in dipolar TADF emitters.

Mouse models of severe congenital neutropenia using patient-derived mutations in the GFI1 locus are used to determine the mechanisms by which the disease progresses.

Here, the authors report that combining Army Liposome Formulation with QS21 saponin (ALFQ) and Alum to formulate the ΔV1gp120 boost decreases the risk of simian immunodeficiency virus (SIV) mac251 acquisition in female macaques.

It is often assumed that systems that can be analyzed accurately via mean-field theory would not be worth looking at using quantum algorithms, given entanglement plays no key role. Here, the authors show instead that a quantum advantage can be expected for simulating the exact time evolution of such electronic systems.

Lipid metabolism regulates stem cell states and differentiation. Here, the authors demonstrate a requirement in planarians for Apolipoprotein B-mediated neutral lipid transport from intestinal stores to stem cells and their progeny during differentiation and whole-body regeneration.

Efficient detection of single molecules is vital to many biosensing technologies, which require analytical platforms with high selectivity and sensitivity. Ren et al. combine a nanopore sensor and a field-effect transistor, whereby gate voltage mediates DNA and protein transport through the nanopore.

The electrical and optical properties of a material depend strongly on the details of its crystal structure. Here, the authors report a technique to mechanically deform the lattice of monolayer graphene with strain, and electrically detect the generation of a scalar potential that modifies the graphene work function.

A new type of Hall effect—the layer Hall effect—is produced in a 2D antiferromagnet that does not exhibit any net magnetization.

By determining the crystal structure of the Na + /H + antiporter NhaA at active pH, the authors show how substrate accessibility to the ion-binding site can be controlled by pH sensitive switch located on the cytoplasmic surface.

Control of CRISPR-Cas9 activity allows for fine-tuning of editing and gene expression. Here the authors use gRNAs modified with RNA aptamers to enable small molecule control in bacterial systems.

Spin and charge dynamics are inevitably linked, the study of the one often illuminating the other. Here, the authors study spin relaxation in ambipolar polymers and, backed by simulations, show how charge dynamics and wavefunction localization together set relaxation times up to room temperature.

A simple programmable quantum processor has been created using trapped atomic ions. The system can be programmed with 15 classical inputs to produce any unitary operation on two qubits. This trapped-ion approach is amenable to scaling up for creating more complex circuits.

Despite their versatility, superconducting qubits such as transmons still have limited coherence times compared to resonators. Here, the authors show how to use a single transmon to implement universal one-qubit and two-qubit operations among nine qubits encoded in superconducting resonators’ eigenmodes.

Donor spin impurities in silicon are promising qubit candidates, but efficient control and coupling of distant spins remains a key challenge. In this work, the authors experimentally demonstrate coherent coupling between a superconducting flux qubit and individual bismuth donor spins in silicon.

Free-electron laser pulses generated from self-amplification of spontaneous emission scheme vary from one another in their characteristics. Here the authors demonstrate a transient absorption spectroscopy method to characterize the frequency chirp of the FEL pulses.

Introducing spin–orbit coupling by substrate proximity effect leads to an enhancement of superconducting phases in rhombohedral trilayer graphene.

The authors have demonstrated a method for real-time imaging of the interior of a battery using ultrasound imaging. This approach reveals effects that hinder fast charging, enabling researchers to develop new batteries and optimize their utilization.

There is growing interest in non-traditional materials for logic applications. Here, the authors demonstrate a domain device architecture based on ferroelectric LiNbO₃ crystals with gate voltage controlled transistor without subthreshold swing and source voltage controlled nonvolatile transistor.

KUP transporters facilitate potassium uptake by the co-transport of protons and are key players in potassium homeostasis. Here authors identify the potassium importer KimA from Bacillus subtilis as a new member of the KUP transporter family and show the cryo-EM structure of KimA in an inward-occluded, trans-inhibited conformation.

Materials formed by linking metal ions with organic ligands have potential for gas adsorption and storage, and can be flexible in response to stimuli. Now, suitable organic linkers result in a material that undergoes a large structural change, but does not lose crystallinity.

Here, the authors use a nanoscale probe to study the photoresponse within a single moiré unit cell of minimally twisted bilayer graphene, and observe an intricate photo-thermoelectric response attributed to the Seebeck coefficient variation at AB-BA domain boundaries.

Here, the authors show robust edge state transport in patterned nanoribbon networks produced on epigraphene—graphene that is epitaxially grown on non-polar faces of SiC wafers. The edge state forms a zero-energy, one-dimensional ballistic network with dissipationless nodes at ribbon–ribbon junctions.

Type-III secretion systems (T3SSs) are capable of translocating proteins with high speed while maintaining the membrane barrier for small molecules. Here, a structure-function analysis of the T3SS pore complex elucidates the precise mechanisms enabling the gating and the conformational changes required for protein substrate secretion.

A large nuclear spin has been successfully placed in a Schrödinger cat state, a superposition of its two most widely separated spin coherent states. This can be used as an error-correctable qubit.

The development of electronic flying qubits requires the ability to generate and control single-electron excitations. Here the authors demonstrate quantum coherence of ultrashort single-electron plasmonic pulses in an electronic Mach-Zehnder interferometer, revealing a non-adiabatic regime at high frequencies.

Traditional regulatory T cell (Tregs) assays utilize mixture of purified cell population. Here the authors develop a ‘single cell suppression profiling of human Tregs’ (scSPOT) with 52-marker CyTOF panel, a cell division detection algorithm, and a whole PBMC system to assess Treg suppressive function on all cell types simultaneously.

The intracellular applications of STED microscopy are limited by the availability of dyes. Here the authors develop a two-colour labelling strategy based on SiR and ATTO590 dyes, and apply their strategy to image various subcellular membrane compartments.

Electrostatically defined quantum dots in graphene constitute a testbed to study atomic and molecular physics in the ultrarelativistic regime—when the particle speed is close to the speed of light. Magnetic-field-dependent tunnelling spectroscopy experiments now reveal giant orbital magnetic moments and paramagnetic shifts in single and double quantum dots due to their relativistic nature.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Transport measurements in twisted bilayer MoTe₂ reveal quantized Hall resistance plateaus and composite Fermi liquid-like behaviour under zero magnetic field, constituting a direct observation of integer and fractional quantum anomalous Hall effects.

Roy-Chowdhury et al. report structures of the human leak channel K_2P13.1 that identify a hydrophilic pore restriction and a polyunsaturated-fatty-acid-binding site corresponding to a small-molecule agonist site in the K_2P family.

Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and are under strong purifying selection in the germline.

The semiconducting ABC configuration of trilayer graphene is more challenging to grow on large scales than its semimetallic ABA counterpart. Here, an approach to trilayer growth via chemical vapor deposition is presented that utilizes substrate curvature to yield enhanced fraction and size of ABC domains.

Quantized conductance in the transport of neutral atoms is observed in an optically produced channel — either a quantum point contact or a quantum wire — between two atom reservoirs; the lowest non-zero conductance value is the universal conductance quantum, the reciprocal of Planck’s constant.

Second-order superlattices emerging in magic-angle twisted bilayer graphene aligned with hexagonal boron nitride are visualized in real space through cryogenic nano-imaging, revealing the impact of strain and twist-angle variations.

AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMPARs still allow ions to flow when the receptors are desensitized.

Gate tunable and ultrabroadband third-harmonic generation can be achieved in graphene, paving the way for electrically tunable broadband frequency converters for applications in optical communications and signal processing.

Whether ballistic transport can occur in a system is usually governed by the number of impurities, but a ballistic transport regime is seen in charge-neutral graphene that is limited not by impurities or phonons, but electron–hole collisions.