Eukaryotic cells contain membrane-bound organelles that can undergo fusion with each other in a regulated manner; this is thought to be mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors). Here, the complete reconstitution of endosome fusion using Rab5 and SNARE proteins highlights the functional relationship between these two machineries.
- Takeshi Ohya
- Marta Miaczynska
- Marino Zerial
