Despite the growing number of X-ray crystal structures of membrane proteins, direct structural information about proteins in their native membrane environment remains scarce. Neutron diffraction, solid-state nuclear magnetic resonance spectroscopy and molecular dynamics simulations are now used to investigate the structure and hydration of bilayer membranes containing S1–S4 voltage-sensing domains.
- Dmitriy Krepkiy
- Mihaela Mihailescu
- Kenton J. Swartz
