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Prostaglandin E₂-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells

Mechanisms of prostaglandin E2 (PGE2)-mediated immunosuppression in the tumor microenvironment (TME) have been previously reported. Here, the authors profile PGE2 functions in human cancer, suggesting that prostaglandin E2-mediated signaling impairs the activity of human CD8+ T cells and macrophages by altering bioenergetics and ribosome biogenesis.

Siwakorn Punyawatthananukool
Ryuma Matsuura
Shuh Narumiya
ResearchOpen Access01 Nov 2024
Nature Communications

Volume: 15, P: 1-19
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

In this study, the authors show that mDia1 and mDia3 are necessary for the tangential migration of interneuron precursors, but are dispensable for radial migration. These proteins act via a Rho/ROCK-mediated pathway to regulate F-actin accumulation and nuclear translocation.

Ryota Shinohara
Dean Thumkeo
Shuh Narumiya
Research15 Jan 2012
Nature Neuroscience

Volume: 15, P: 373-380
Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response

Thamrong Wongchang
Panwadee Pluangnooch
Kitipong Soontrapa
ResearchOpen Access29 Apr 2023
Scientific Reports

Volume: 13, P: 1-11

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