The development of a Late-stage functionalization strategy to introduce functionalizable groups provides a toolbox for future drug discovery. Herein, the authors report a synthetic strategy for the N-methyl selective alkenylation and alkynylation of aliphatic tertiary amines using organophotoredox catalysis, and its application to the late-stage functionalization of marketed drugs.
- Swagata Paul
- Somenath Mahato
- Santanu Panda
