Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Deblina Raychaudhuri Clear advanced filters

  • Genes encoding key epigenetic regulators, including Lysine Demethylase 6A (KDM6A), are frequently mutated in bladder cancer. Here, the authors show that loss of KDM6A promotes formation of extrachromosomal circular DNA (eccDNA), genomic instability, and metabolic reprogramming, driving resistance to cisplatin chemotherapy while simultaneously enhancing sensitivity to immune checkpoint inhibitors.

    • Pratishtha Singh
    • Ranit D’Rozario
    • Sangeeta Goswami
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-23

  • Goswami and colleagues describe how lactylation of histone lysine residues regulates the transcriptome, metabolism and function of CD8+ T cells.

    • Deblina Raychaudhuri
    • Pratishtha Singh
    • Sangeeta Goswami
    Research
    Nature Immunology
    Volume: 25, P: 2140-2151

  • Goswami and colleagues identify high expression of KDM6B in immune-suppressive myeloid cells in glioblastoma and show that its myeloid cell-specific deletion enhances inflammatory signaling and antigen presentation, thereby extending survival.

    • Sangeeta Goswami
    • Deblina Raychaudhuri
    • Padmanee Sharma
    Research
    Nature Cancer
    Volume: 4, P: 1455-1473

  • Convalescent plasma therapy (CPT) is used to treat patients with Covid-19, but evidence for clinical benefit from clinical trials is divergent. Here the authors report in that CPT treatment does not affect mortality in patients with severe Covid-19 in phase 2 single center open label randomised controlled trial.

    • Yogiraj Ray
    • Shekhar Ranjan Paul
    • Dipyaman Ganguly
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Myeloid cells contribute to the immunosuppressive tumour microenvironment and can be responsible for resistance to cancer immunotherapy. Here, the authors describe the current therapies that aim to modulate the functional activities of myeloid cell populations, impacting their recruitment, survival and activity in the tumour microenvironment, acting at the level of cell surface receptors, signalling pathways, epigenetic machinery and metabolic regulators.

    • Sangeeta Goswami
    • Swetha Anandhan
    • Padmanee Sharma
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 106-120