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Showing 1–5 of 5 results
Advanced filters: Author: Debosmita Sardar Clear advanced filters

  • Astrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10, and this clearance of plaques is associated with the preservation of cognitive function in mouse models.

    • Dong-Joo Choi
    • Sanjana Murali
    • Benjamin Deneen
    Research
    Nature Neuroscience
    Volume: 29, P: 88-99

  • Chemicals derived from neurotransmitter molecules in the brain can act as epigenetic marks on histone proteins to regulate gene expression. These marks control circadian clock genes and influence behaviour.

    • Debosmita Sardar
    • Tatiana G. Kutateladze
    News & Views
    Nature
    Volume: 637, P: 795-796

  • A study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astrocytes are involved in the recall of memories.

    • Michael R. Williamson
    • Wookbong Kwon
    • Benjamin Deneen
    Research
    Nature
    Volume: 637, P: 478-486

  • Serotonin has a role in ependymoma tumorigenesis through modifying histones and thereby regulating key transcription factors and activating specific oncogenic transcriptional networks in brain cells.

    • Hsiao-Chi Chen
    • Peihao He
    • Benjamin Deneen
    Research
    Nature
    Volume: 632, P: 903-910