The GABA transporters (GATs) enforce spatiotemporal control of the inhibitory neurotransmitter GABA at neural synapses. Nayak et al. report the structure of substrate-bound GAT1 in an ion-bound cytosol-facing conformation, providing mechanistic insights into GABA selection and reuptake.
- Smruti Ranjan Nayak
- Deepthi Joseph
- Aravind Penmatsa
