Nature Search

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

S E Legge
M L Hamshere
J T R Walters
ResearchOpen Access12 Jul 2016
Molecular Psychiatry

Volume: 22, P: 1502-1508
Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes

A library of fluorogenic dyes enables the measurement of protein unfolding for a large range of proteins.

Taiasean Wu
Joshua C. Yu
Jason E. Gestwicki
Research14 May 2024
Nature Biotechnology

Volume: 43, P: 106-113
Pioneering protein degradation for agricultural applications

Development of VHL-recruiting PROTACs that degrade fall armyworm sfBRD3 and sfWDS proteins with high potencies in Sf9 cells and in full larvae, establishing the PROTAC modality as promising for agricultural applications.

Gina L. Morgan
Hamilton Dickson
Denis Fourches
ResearchOpen Access09 Apr 2025
Communications Biology

Volume: 8, P: 1-12
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Clozapine-induced agranulocytosis/granulocytopenia, or CIAG, is characterised by a rare and potentially fatal reaction to antipsychotic drugs. Here, the authors identify genetic variants in two immune-related genes that may contribute to the pathophysiology of CIAG.

Jacqueline I. Goldstein
L. Fredrik Jarskog
Patrick F. Sullivan
Research04 Sept 2014
Nature Communications

Volume: 5, P: 1-9
Curation of chemogenomics data

Denis Fourches
Eugene Muratov
Alexander Tropsha
Correspondence21 Jul 2015
Nature Chemical Biology

Volume: 11, P: 535
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17
Comprehensive characterization of the Published Kinase Inhibitor Set

A well-characterized library of experimental kinase inhibitors provides leads for targeting the untargeted kinome.

Jonathan M Elkins
Vita Fedele
William J Zuercher
Research01 Jan 2016
Nature Biotechnology

Volume: 34, P: 95-103
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

Debabrata Mahapatra
Jill A. Franzosa
Seth W. Kullman
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-16

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Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes

Pioneering protein degradation for agricultural applications

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Curation of chemogenomics data

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Comprehensive characterization of the Published Kinase Inhibitor Set

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

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