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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells

Here, the authors show that combining γ9δ2 TCR-mediated metabolic and co-stimulatory stress targeting by chimeric NKG2D or anti-CD277 co-receptors shapes transcriptomic heterogeneity of engineered T cells and is associated with improved control of solid tumors.

Patricia Hernández-López
Eline van Diest
Jürgen Kuball
Research27 Nov 2023
Nature Immunology

Volume: 25, P: 88-101
Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy

In this Review, Beringer and colleagues highlight how future strategies for developing immunotherapies using γδT cells and their receptors will depend on creating intentional imbalances between activating and inhibitory receptors through the genetic engineering of γδT cell-inspired biologics and cellular therapies.

Dennis X. Beringer
Trudy Straetemans
Jürgen Kuball
Reviews02 Jun 2025
Nature Reviews Cancer

Volume: 25, P: 590-612
Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control

Patricia Hernández-López
Caterina Riillo
Dennis X. Beringer
Research10 Dec 2025
Cellular & Molecular Immunology

Volume: 23, P: 79-93
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

To date, structural analysis has demonstrated a highly consistent binding pattern of the TCR to the MHC molecule. Rossjohn and colleagues reveal the first structures of two human T_reg cell TCRs and show that they bind with a reversed polarity to the MHC.

Dennis X Beringer
Fleur S Kleijwegt
Jamie Rossjohn
Research05 Oct 2015
Nature Immunology

Volume: 16, P: 1153-1161
Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Human leukocyte antigen (HLA) presents peptides to activate T cells, but many aspects in the T cell receptor (TCR)/HLA interaction remain unclear. Here the authors show, via structural data, that two TCRs differentially recognize the same tumour peptide/HLA complex and induce contrasting conformation changes of the peptide.

Kok Fei Chan
Benjamin S. Gully
Jamie Rossjohn
ResearchOpen Access12 Mar 2018
Nature Communications

Volume: 9, P: 1-13
T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

A central event in celiac disease (CD) is the recognition by TCRs of gluten epitopes presented by specific HLAs, with HLA-DQ2 being associated with 95% of CD cases. The molecular basis for these interactions are now revealed by crystal structures of TCRs from individuals with CD in complex with wheat gliadin epitopes presented by HLA-DQ2.

Jan Petersen
Veronica Montserrat
Jamie Rossjohn
Research28 Apr 2014
Nature Structural & Molecular Biology

Volume: 21, P: 480-488
The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

Gilberto Pastorello
Carlo Trotta
Dario Papale
ResearchOpen Access09 Jul 2020
Scientific Data

Volume: 7, P: 1-27

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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells

Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy

Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data

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