Nature Search

Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase

Vitamin K-dependent carboxylation is vital for human health. Here, authors present cryo-EM structures of the relevant γ-glutamyl carboxylase, uncovering substrate recognition, processive modification, and a bicarbonate-mediated CO₂ fixation mechanism.

Ke Wu
Zheng Wang
Pengfei Lan
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas

Sibo Zhao
Jia Li
Xiao-Nan Li
Amendments and CorrectionsOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Hind Rafei
Rafet Basar
Katayoun Rezvani
ResearchOpen Access04 Jun 2025
Nature

Volume: 643, P: 1076-1086
The structural insight into the functional modulation of human anion exchanger 3

This study provides structural insights into human AE3’s role in pH regulation in excitable tissues, highlighting its structural differences from AE2 in anion transport regulation and their sensitivity to inhibitors.

Liyan Jian
Qing Zhang
Yu Cao
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-13
The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

During phosphatidylcholine (PC) remodeling re-acylation is catalyzed by lysophosphatidylcholine acyltransferases (LPCAT). Here, the authors present crystal and cryo-EM structures of chicken LPCAT3 in the apo-, acyl donor-bound and acyl receptor-bound states, and based on the structures and further functional analysis they discuss the mechanism of the enzyme.

Qing Zhang
Deqiang Yao
Yu Cao
ResearchOpen Access25 Nov 2021
Nature Communications

Volume: 12, P: 1-11
The structural basis of the pH-homeostasis mediated by the Cl⁻/HCO₃⁻ exchanger, AE2

Cells maintain a narrow physiological pH by exchanging intracellular bicarbonate for extracellular chloride. Here, authors determine the cryo-EM structures of human anion exchanger 2 (AE2) in five major operating states and one transitional state, to collectively demonstrate the process of pH-balancing.

Qing Zhang
Liyan Jian
Yu Cao
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-11
The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase

Hypophosphatasia (HPP) is a bone disease caused by mutations in tissue non-specific alkaline phosphatase (TNAP). Here, authors solved the crystal and cryoEM structures of TNAP, shedding light on the molecular mechanisms underlying HPP.

Yating Yu
Kewei Rong
An Qin
ResearchOpen Access08 Jul 2023
Nature Communications

Volume: 14, P: 1-14
Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

Zhichao Lai
Deqiang Kong
Xin Liu
Research28 Apr 2025
Nature Cardiovascular Research

Volume: 4, P: 547-566
Affinity molecular assay for detecting Candida albicans using chitin affinity and RPA-CRISPR/Cas12a

IFIs pose a significant threat to immunocompromised individuals, and there is an urgent need for rapid and sensitive diagnostic assays. Here, the authors present a rapid molecular diagnostic method based on magnetic fungal enrichment and CRISPR-based detection.

Shimei Shen
Wen Wang
Deqiang Wang
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus

Multi-omics analysis reveals that differential plant performance among Populus species is associated with Pseudomonas in the rhizosphere. Further mechanistic investigation identifies GL3 as a regulator of flavone biosynthesis contributing to Pseudomonas recruitment.

Jiadong Wu
Sijia Liu
Deqiang Zhang
ResearchOpen Access07 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis

Researchers unveiled the structural details of sphingomyelin synthase (SMSr), shedding light on its role in sphingolipid biosynthesis. SMSr transfers the phosphoethanolamine from PE to ceramide, adding complexity to the field of lipid homeostasis.

Kexin Hu
Qing Zhang
Yu Cao
Research22 Feb 2024
Nature Structural & Molecular Biology

Volume: 31, P: 884-895
Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue

Wolbachia induced cytoplasmic incompatibility (CI) is caused by linked pairs of genes named cifA and cifB. Here, authors show that the residues at interfaces of the CidA-CidB complex is crucial for their binding and contribute to the diversity of CI.

Haofeng Wang
Yunjie Xiao
Haitao Yang
ResearchOpen Access25 Mar 2022
Nature Communications

Volume: 13, P: 1-11
Cryo-EM structure of the human Derlin-1/p97 complex reveals a hexameric channel in ERAD

Structural insights into the Derlin-1/p97 complex reveal a dynamic 6:6 architecture that expands the ERAD retrotranslocation pathway, highlighting ATPase-powered plasticity in processing bulky substrates.

Qian Wang
Deqiang Yao
Yu Cao
ResearchOpen Access17 Oct 2025
Communications Biology

Volume: 8, P: 1-9
Author Correction: Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice

Yidan Wang
Ying Xu
Haifeng Ye
Amendments and CorrectionsOpen Access05 Jul 2023
Nature Communications

Volume: 14, P: 1
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin

Zhang et al. report that the lncRNA H19 stabilizes dystrophin by competing with the ubiquitin E3 ligase TRIM63 for association with dystrophin, thereby alleviating muscular dystrophies.

Yaohua Zhang
Yajuan Li
Liuqing Yang
Research26 Oct 2020
Nature Cell Biology

Volume: 22, P: 1332-1345
Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis

Xiaoyu Zhang
Qiuyue Tian
Youxin Wang
ResearchOpen Access12 May 2020
Translational Psychiatry

Volume: 10, P: 1-8
Publisher Correction: Electric-field control of ferromagnetism through oxygen ion gating

Hao-Bo Li
Nianpeng Lu
Pu Yu
Amendments and CorrectionsOpen Access05 Feb 2018
Nature Communications

Volume: 9, P: 1-2
Monitoring tetracycline through a solid-state nanopore sensor

Yuechuan Zhang
Yanling Chen
Deqiang Wang
ResearchOpen Access16 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Grinding wheel wear evaluation with the PMSCNN model

Sumei Si
Zekai Si
Hailiang Tang
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Large conserved domains of low DNA methylation maintained by Dnmt3a

Margaret Goodell and colleagues report genome-wide mapping of 5-methylcytosine and 5-hydroxymethylcytosine in purified mouse hematopoietic stem cells. They identify large regions of low methylation with borders marked by 5-hydroxymethylcytosine. These borders become eroded in the absence of DNA methyltransferase 3a.

Mira Jeong
Deqiang Sun
Margaret A Goodell
Research24 Nov 2013
Nature Genetics

Volume: 46, P: 17-23
AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation

Long-term control of therapeutic transgene expression is needed. Here the authors report a muscone-induced transgene system packaged into AAVs based on a G protein-coupled murine olfactory receptor and a synthetic cAMP-responsive promoter: they show dose- and exposure-time-dependent gene expression control in mice.

Xin Wu
Yuanhuan Yu
Haifeng Ye
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.

Sibo Zhao
Jia Li
Xiao-Nan Li
ResearchOpen Access05 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi

Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.

Min He
Jia Su
Xuewei Chen
Research21 Sept 2020
Nature Microbiology

Volume: 5, P: 1565-1575
Neoadjuvant toripalimab plus axitinib for clear cell renal cell carcinoma with inferior vena cava tumor thrombus: NEOTAX, a phase 2 study

Liangyou Gu
Cheng Peng
Xin Ma
ResearchOpen Access04 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Research on motion tracking and impact force detection of flying objects

Xiaodong Li
Enzhong Zhang
Deqiang Mu
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions

The increase in detoxification gene expression is a common transcriptome marker for longevity interventions. Here, the authors show that nomilin extends lifespan and healthspan in animals through activation of PXR regulated detoxification functions.

Shengjie Fan
Yingxuan Yan
Cheng Huang
ResearchOpen Access08 Jun 2023
Nature Communications

Volume: 14, P: 1-23
First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study

Xiaofeng Chen
Hao Xu
Yongqian Shu
ResearchOpen Access25 Mar 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-8
Hepatoprotective role of Sestrin2 against chronic ER stress

When exposed to chronic endoplasmic reticulum (ER) stress, cells downregulate protein synthesis by inhibiting mTOR signalling. Park et al.identify Sestrin2 as a transcriptional target of the ER stress pathway and an important mediator of this protective response in the liver.

Hwan-Woo Park
Haeli Park
Jun Hee Lee
Research20 Jun 2014
Nature Communications

Volume: 5, P: 1-11
Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice

The development of broad-spectrum antivirals is an important part of pandemic preparedness and response. Here the authors present ALICE, synthetic biology designer immune-like cells that act as a sense-and-destroy antiviral system can detect viruses from seven different genera, mimicking the human innate immune system.

Yidan Wang
Ying Xu
Haifeng Ye
ResearchOpen Access09 Dec 2022
Nature Communications

Volume: 13, P: 1-18
Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development

Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in regulating chromatin organization during early heart development.

Shaohai Fang
Jia Li
Yun Huang
ResearchOpen Access20 Sept 2019
Nature Communications

Volume: 10, P: 1-18
CTCF participates in DNA damage response via poly(ADP-ribosyl)ation

Deqiang Han
Qian Chen
Xiaochun Yu
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes

Chongwei Chi
Qian Zhang
Jie Tian
ResearchOpen Access23 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
Macrophages induce AKT/β-catenin-dependent Lgr5⁺ stem cell activation and hair follicle regeneration through TNF

Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.

Xusheng Wang
Haiyan Chen
Yaojiong Wu
ResearchOpen Access27 Mar 2017
Nature Communications

Volume: 8, P: 1-14
Electric-field control of ferromagnetism through oxygen ion gating

It has been suggested that the magnetic properties of metal layers using reversible redox reactions could form the basis of memory devices but this requires fast electric control to be practical. Here the authors demonstrate this on sub-millisecond timescales in a metal–oxide heterostructure.

Hao-Bo Li
Nianpeng Lu
Pu Yu
ResearchOpen Access18 Dec 2017
Nature Communications

Volume: 8, P: 1-7
A study of the relationship and drivers between participation in sports program diversity and physical fitness

Deqiang Zhao
Xiaoxiao Chen
Yanfeng Zhang
ResearchOpen Access15 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Highly efficient hybrid warm white organic light-emitting diodes using a blue thermally activated delayed fluorescence emitter: exploiting the external heavy-atom effect

Dongdong Zhang
Lian Duan
Yong Qiu
ResearchOpen Access02 Jan 2015
Light: Science & Applications

Volume: 4, P: e232
Extracorporeal delivery of a therapeutic enzyme

Chun Zhang
Jun Pu
Fei Liao
ResearchOpen Access01 Aug 2016
Scientific Reports

Volume: 6, P: 1-8
Exogenous selenium mitigates cadmium uptake and accumulation in two rice (Oryza sativa L.) varieties in cadmium-contaminated soil

Wenjiang Wu
Deqiang Qi
Ting Peng
ResearchOpen Access11 Sept 2024
Scientific Reports

Volume: 14, P: 1-14
Conserved noncoding sequences conserve biological networks and influence genome evolution

Jianbo Xie
Kecheng Qian
Deqiang Zhang
Research03 Feb 2018
Heredity

Volume: 120, P: 437-451
The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea Virus

Kang Wang
Chun Xie
Guangzhi Tong
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
Publisher Correction: Integrated analysis of a compendium of RNA-Seq datasets for splicing factors

Peng Yu
Jin Li
Peng Jin
Amendments and CorrectionsOpen Access07 Aug 2020
Scientific Data

Volume: 7, P: 1
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance

Jixiang Zhang
Peng Tan
Yun Huang
Research02 Nov 2018
Oncogene

Volume: 38, P: 1905-1919
Effects of thinning and understory removal on the soil water-holding capacity in Pinus massoniana plantations

Ting Wang
Qing Xu
Jing Jiang
ResearchOpen Access22 Jun 2021
Scientific Reports

Volume: 11, P: 1-13
The genetic regulatory network centered on Pto-Wuschela and its targets involved in wood formation revealed by association studies

Xiaohui Yang
Zunzheng Wei
Deqiang Zhang
ResearchOpen Access09 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Association genetics in Populus reveals the interactions between Pt-miR397a and its target genes

Jinhui Chen
Beibei Chen
Deqiang Zhang
ResearchOpen Access26 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
An integrated transcriptome, metabolome, and microbiome dataset of Populus under nutrient-poor conditions

Jiadong Wu
Dongyan He
Jianbo Xie
ResearchOpen Access30 Apr 2025
Scientific Data

Volume: 12, P: 1-11
Microstructure and domain engineering of lithium niobate crystal films for integrated photonic applications

Dehui Sun
Yunwu Zhang
Hong Liu
ReviewsOpen Access10 Dec 2020
Light: Science & Applications

Volume: 9, P: 1-18
Integrated analysis of a compendium of RNA-Seq datasets for splicing factors

Peng Yu
Jin Li
Peng Jin
ResearchOpen Access16 Jun 2020
Scientific Data

Volume: 7, P: 1-16
A meta-analysis of DNA repair gene XPC polymorphisms and cancer risk

Deqiang Zhang
Chengwen Chen
Yao Li
Research01 Jan 2008
Journal of Human Genetics

Volume: 53, P: 18-33

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