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Showing 1–7 of 7 results
Advanced filters: Author: Derek Oldridge Clear advanced filters

  • Lee and colleagues present AdaSlide, an AI-driven adaptive compression system for gigapixel pathology slides that preserves diagnostic quality while reducing storage by up to 90%, enabling scalable and cost-efficient digital pathology archiving.

    • Jonghyun Lee
    • Lina Takemaru
    • Sung Hak Lee
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • John Maris, Jan Molenaar, Gudrun Schleiermacher and colleagues performed whole-genome sequencing of 23 paired diagnostic and relapsed neuroblastomas, showing enrichment for mutations in the RAS-MAPK signaling pathway. These mutations render neuroblastoma cell lines susceptible to MEK inhibition.

    • Thomas F Eleveld
    • Derek A Oldridge
    • John M Maris
    Research
    Nature Genetics
    Volume: 47, P: 864-871

  • Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2 related syndromes and find disproportionately high IFN-γ responses in MIS-C patients.

    • Caroline Diorio
    • Rawan Shraim
    • Edward M. Behrens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • A study of hospitalized patients infected with SARS-CoV-2 and who have liquid or solid cancer suggests that hematologic malignancy is an independent risk factor for mortality and that CD8+ T cells might limit infection in this setting irrespective of humoral immunity.

    • Erin M. Bange
    • Nicholas A. Han
    • Alexander C. Huang
    Research
    Nature Medicine
    Volume: 27, P: 1280-1289

  • A causal variant is identified at the LMO1 oncogene locus that drives the genetic association of LMO1 with neuroblastoma susceptibility; the causal SNP disrupts a GATA transcription factor binding site within a tissue-specific super-enhancer element in the first intron of LMO1, thereby affecting LMO1 expression.

    • Derek A. Oldridge
    • Andrew C. Wood
    • John M. Maris
    Research
    Nature
    Volume: 528, P: 418-421

  • The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

    • Denis Schapiro
    • Clarence Yapp
    • Peter K. Sorger
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 262-267