Nature Search

Advances in vaccine adjuvants

Manmohan Singh
Derek O'Hagan
Reviews01 Nov 1999
Nature Biotechnology

Volume: 17, P: 1075-1081
The droplet size of emulsion adjuvants has significant impact on their potency, due to differences in immune cell-recruitment and -activation

Ruchi R. Shah
Marianna Taccone
Anja Seubert
ResearchOpen Access08 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Trials in rhesus macaques show that a subunit vaccine against SARS-CoV-2, comprising the spike protein receptor-binding domain displayed on a nanoparticle protein scaffold, produces a robust protective response against the virus.

Prabhu S. Arunachalam
Alexandra C. Walls
Bali Pulendran
Research19 Apr 2021
Nature

Volume: 594, P: 253-258
Analysis of immunoglobulin transcripts and hypermutation following SHIV_AD8 infection and protein-plus-adjuvant immunization

HIV vaccine development will be facilitated by having animal models that are predictive for translation to humans. Here, the authors use two nonhuman primate models to compare the effects of natural infection and different adjuvants on antigen persistence, diversity and humoral immunity.

Joseph R. Francica
Zizhang Sheng
Robert A. Seder
ResearchOpen Access10 Apr 2015
Nature Communications

Volume: 6, P: 1-14
Recent advances in the discovery and delivery of vaccine adjuvants

Derek T. O'Hagan
Nicholas M. Valiante
Reviews01 Sept 2003
Nature Reviews Drug Discovery

Volume: 2, P: 727-735
Emerging concepts in the science of vaccine adjuvants

This Review discusses how recent advances in understanding the activation of the innate immune system are shedding light on the immunological mechanisms of action of adjuvants and highlights how systems-based approaches are beginning to revitalize adjuvant design and development.

Bali Pulendran
Prabhu S. Arunachalam
Derek T. O’Hagan
Reviews06 Apr 2021
Nature Reviews Drug Discovery

Volume: 20, P: 454-475
Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines

Giuseppe Lofano
Corey P. Mallett
Derek T. O’Hagan
ReviewsOpen Access18 Sept 2020
npj Vaccines

Volume: 5, P: 1-13
Author Correction: “World in motion” – emulsion adjuvants rising to meet the pandemic challenges

Derek T. O’Hagan
Robbert van der Most
Giuseppe Lofano
Amendments and CorrectionsOpen Access02 Feb 2023
npj Vaccines

Volume: 8, P: 1
Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice

Lilit Grigoryan
Audrey Lee
Bali Pulendran
ResearchOpen Access23 May 2022
npj Vaccines

Volume: 7, P: 1-14
Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines

Cecilia Buonsanti
Cristiana Balocchi
Ugo D’Oro
ResearchOpen Access21 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
The scientific journey of a novel adjuvant (AS37) from bench to bedside

Ugo D’Oro
Derek T. O’Hagan
ReviewsOpen Access08 Feb 2024
npj Vaccines

Volume: 9, P: 1-8
“World in motion” – emulsion adjuvants rising to meet the pandemic challenges

Derek T. O’Hagan
Robbert van der Most
Giuseppe Lofano
ReviewsOpen Access21 Dec 2021
npj Vaccines

Volume: 6, P: 1-15
Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

Harm HogenEsch
Derek T. O’Hagan
Christopher B. Fox
ReviewsOpen Access10 Oct 2018
npj Vaccines

Volume: 3, P: 1-11

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