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Showing 1–5 of 5 results

Advanced filters: Author: Devan Phillips Clear advanced filters

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution

Here they developed an inflamed human intestinal organoid model and used it to build a scRNA-seq perturbation atlas of microenvironmental cues in the context of inflammatory bowel disease.

Meghan M. Capeling
Bob Chen
Michelle B. Chen
ResearchOpen Access09 Jan 2026
Nature Communications

Volume: 17, P: 1-15
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe COVID-19 infection.

Toni M. Delorey
Carly G. K. Ziegler
Aviv Regev
Research29 Apr 2021
Nature

Volume: 595, P: 107-113
Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain

Single-nucleus RNA sequencing from the dorsolateral prefrontal cortex of 424 aging individuals, and mapping the effect of genetic variation on gene expression, identified a large number of cis-expression quantitative trait loci at the level of cell types and cell subtypes.

Masashi Fujita
Zongmei Gao
Philip L. De Jager
Research21 Mar 2024
Nature Genetics

Volume: 56, P: 605-614
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

Single-nucleus and spatial, whole-transcriptome profiling of 43 pancreatic adenocarcinomas provides a refined molecular and cellular classification, highlighting a new neoadjuvant treatment-associated neural-like progenitor tumor cell state.

William L. Hwang
Karthik A. Jagadeesh
Aviv Regev
Research28 Jul 2022
Nature Genetics

Volume: 54, P: 1178-1191
Joint single-cell measurements of nuclear proteins and RNA in vivo

This work describes inCITE-seq that jointly measures intranuclear protein levels and the transcriptome in single nuclei, which is applied to mouse brain tissue to relate quantitative protein levels of TFs to gene expression programs.

Hattie Chung
Christopher N. Parkhurst
Aviv Regev
Research04 Oct 2021
Nature Methods

Volume: 18, P: 1204-1212