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Showing 1–3 of 3 results
Advanced filters: Author: Devanshi Jain Clear advanced filters

  • PNMA-family genes are gag-like elements of ancient retrotransposon origin whose roles in mammalian genomes is incompletely understood. Wood et al. found that two retrotransposon-derived proteins, PNMA1 and PNMA4, support mammalian fertility in both sexes and become increasingly important during aging. These proteins assemble into capsid-like structures that contain RNA and exit human cells.

    • Thomas W. P. Wood
    • William S. Henriques
    • Luke E. Berchowitz
    Research
    Nature Aging
    Volume: 5, P: 765-779

  • The ends of eukaryotic chromosomes are composed of repeat sequences known as telomeres. Various proteins bind telomeres to protect them from degradation or inappropriate DNA repair responses, and their length is maintained by a specialized reverse transcriptase, telomerase. These authors show that in the absence of telomerase, telomeres can be maintained by amplifying and recombining heterochromatin sequences there. This process requires histone methylation and two telomere-binding proteins, Pot1 and Ccq1.

    • Devanshi Jain
    • Anna K. Hebden
    • Julia Promisel Cooper
    Research
    Nature
    Volume: 467, P: 223-227