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Showing 1–11 of 11 results
Advanced filters: Author: Dimple Notani Clear advanced filters

  • In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties.

    • Gerd A. Blobel
    • Douglas R. Higgs
    • Richard A. Young
    Reviews
    Nature Reviews Genetics
    Volume: 22, P: 749-755

  • In this Journal Club, Dimple Notani discusses a study that demonstrates a tumour suppressive function of the androgen receptor in oestrogen receptor-positive breast cancer.

    • Dimple Notani
    Research Highlights
    Nature Reviews Cancer
    Volume: 25, P: 398

  • Dimple Notani highlights a 1981 paper by Banerji et al. that describes the discovery of viral enhancer elements and that continues to shape her research today.

    • Dimple Notani
    Research Highlights
    Nature Reviews Genetics
    Volume: 23, P: 522-523

  • Current polygenic risk scores for prostate cancer do not leverage biological mechanisms and remain inadequate for patients with African ancestry. Here, the authors employ a deep learning model to identify 2,407 non-coding polymorphisms with greater frequency in African American individuals that may affect enhancer activity in prostate cancer-related pathways, leading to more accurate polygenic risk scores.

    • Shan Li
    • Kaniz Fatema
    • Sridhar Hannenhalli
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, eRNA transcription is shown to be functionally important during the activation of genes by the oestrogen receptor in human breast cancer cells.

    • Wenbo Li
    • Dimple Notani
    • Michael G. Rosenfeld
    Research
    Nature
    Volume: 498, P: 516-520

  • Genetic variants on chromosome 8q24 are associated with prostate cancer risk in men of African ancestry. Here the authors show that one of these variants, rs72725854 alters the enhancer activity in its region, which upon androgen stimulation, activates multiple oncogenic lncRNAs and c-myc.

    • Kaivalya Walavalkar
    • Bharath Saravanan
    • Dimple Notani
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • A non-coding region on chromosome 9p21 was previously shown to associate with coronary artery disease and type 2 diabetes, and the region has been implicated in regulating neighbouring genes. Here, 33 distinct enhancers within this region are identified, showing that SNPs in one of the enhancers affect STAT1 binding. Furthermore, it is shown that in human vascular endothelial cells the enhancer interval physically interacts with a number of specific loci and that IFN-γ activation strongly affects the chromatin structure and transcriptional regulation of the 9p21 locus, including STAT1 binding, long-range enhancer interactions and expression of neighbouring genes.

    • Olivier Harismendy
    • Dimple Notani
    • Kelly A. Frazer
    Research
    Nature
    Volume: 470, P: 264-268

  • The observation that many, if not all, functional enhancers generate non-coding enhancer RNAs (eRNAs) has raised critical questions regarding the potential biological roles of the enhancer transcription process and, indeed, of eRNAs. This article reviews fundamental insights into the inter-regulation of enhancers and promoters and discusses unresolved questions regarding the functional role of enhancers as transcription units in genome regulation.

    • Wenbo Li
    • Dimple Notani
    • Michael G. Rosenfeld
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 207-223

  • The POU homeodomain transcription factor Pit1 is required for pituitary development; here Pit1-occupied enhancers are shown to interact with the nuclear architecture components matrin-3 and Satb1, and this association is required for activation of Pit1-regulated enhancers and coding target genes.

    • Dorota Skowronska-Krawczyk
    • Qi Ma
    • Michael G. Rosenfeld
    Research
    Nature
    Volume: 514, P: 257-261