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Showing 1–10 of 10 results
Advanced filters: Author: Dina Zielinski Clear advanced filters

  • 23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fall of the company, once valued at US $6 billion and now being considered for acquisition by Regeneron for merely $250 million. Key challenges faced by 23andMe in monetizing its genomic data reveal that this information, at least in a typical DTC setting, is simply not worth that much.

    • Yaniv Erlich
    • Dina Zielinski
    Comments & Opinion
    Nature Biotechnology
    Volume: 43, P: 854-856

  • In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.

    • Antoine Campagne
    • Ming-Kang Lee
    • Raphaël Margueron
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Here, the authors map X-chromosome activity during female mouse germ cell reprogramming, revealing gradual, region-specific gene reactivation. Some genes resist reactivation, retaining epigenetic memory, offering insights into female germline epigenetics.

    • Clara Roidor
    • Laurène Syx
    • Maud Borensztein
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 926-939

  • Some autosomal genes are expressed in a random monoallelic manner, but its extent and mechanisms have remained unclear. Here the authors show robust monoallelic expression in cell lines and mice, where the silent allele can be reexpressed using epidrugs. Further, they find these genes display various modalities of allelic expression with different degrees of allelic imbalance.

    • Lucile Marion-Poll
    • Benjamin Forêt
    • Edith Heard
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity of PRC2 in germ cells in mice.

    • Roberta Ragazzini
    • Raquel Pérez-Palacios
    • Raphaël Margueron
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18