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Showing 1–5 of 5 results
Advanced filters: Author: Dingran Chang Clear advanced filters

  • Generating aptamers for use as affinity reagents in analytical applications is important, but SELEX, the standard method for aptamer generation, is unable to select for pre-defined binding affinities. Now, by combining efficient particle display, high-performance microfluidic sorting and high-content bioinformatics, the method ‘Pro-SELEX’ can afford the quantitative generation of aptamers with programmable binding affinities.

    • Dingran Chang
    • Zongjie Wang
    • Shana O. Kelley
    Research
    Nature Chemistry
    Volume: 15, P: 773-780

  • Methods to detect and identify bacteria typically rely on enrichment steps such as bacterial culture and nucleic acid amplification. Now, an assay for detecting bacteria based on a two-channel electrical chip that combines electroactive DNAzymes with an electrochemical readout, has been developed. This assay enables reagentless and culture-free detection of bacteria in clinical samples.

    • Richa Pandey
    • Dingran Chang
    • Leyla Soleymani
    Research
    Nature Chemistry
    Volume: 13, P: 895-901

  • The intrinsic properties of graphene and the resulting device performance are hindered by the impurities produced during the synthesis process. Here, the authors elucidate the origin of contaminations in CVD-grown graphene and devise a strategy towards the scalable production of ultra-clean graphene with >99% clean regions and low contact resistance.

    • Li Lin
    • Jincan Zhang
    • Zhongfan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • Continuous monitoring of diverse biomolecular signatures has the potential to transform our understanding of personalized and preventative medicine. This Review Article discusses the emerging trends and pertinent considerations for the development of a new generation of body-based biomolecular sensors for in vivo measurement.

    • Connor D. Flynn
    • Dingran Chang
    • Shana O. Kelley
    Reviews
    Nature Reviews Bioengineering
    Volume: 1, P: 560-575