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Showing 1–10 of 10 results
Advanced filters: Author: Dirk Homann Clear advanced filters

  • This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. The authors also provide guidance on how T cell nomenclature should be described in research papers.

    • David Masopust
    • Amit Awasthi
    • Rafi Ahmed
    Reviews
    Nature Reviews Immunology
    P: 1-16

  • Although CD4+ T cell help is required for effective pathogen control, persistent antiviral CD4+ T cell help can, paradoxically, impair the generation of neutralizing antibody responses and thus potentially limit protective immunity.

    • Dirk Homann
    • Ronald G Gill
    News & Views
    Nature Immunology
    Volume: 5, P: 878-880

  • During oral tolerance cells communicate with each other to dampen the immune response, creating an agreeable environment for oral antigens. Even T cells directed against non-oral antigens are suppressed, generating a response known as the 'bystander effect'. Dendritic cells now emerge as mediators of this communication.

    • Matthias von Herrath
    • Dirk Homann
    News & Views
    Nature Medicine
    Volume: 10, P: 585-587

  • ChREBP is a glucose-responsive transcription factor, which regulates glucose-mediated proliferation and cell death in pancreatic β-cells. Here the authors show that the acute feed forward induction of ChREBPβ is required for adaptive β-cell expansion, that chronic overexpression of ChREBPβ is toxic to β-cells, and offer mitigation strategies

    • Liora S. Katz
    • Gabriel Brill
    • Donald K. Scott
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Heeger and colleagues report that activated B cells dynamically regulate the expression of complement regulatory proteins via the transcription factor BCL6. C3 convertase activity and C3aR1–C5aR1 signaling were both necessary for optimal B cell activation and germinal center formation.

    • Arun Cumpelik
    • David Heja
    • Peter S. Heeger
    Research
    Nature Immunology
    Volume: 22, P: 757-768

  • This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

    • Nicolas Vabret
    • Robert Samstein
    • Uri Laserson
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 20, P: 338