Dennis Eickelbeck et al. engineered light-activated constructs, CaMello and CaMello-5HT2A, which are targeted to the 5HT2A-R domains and enable visualization of calcium signals and receptor trafficking in response to activation. The reported CaMello tool could be applied to other GPCRs coupled to the Gq/11 signaling pathways which may shed light on mechanisms of GPCR localization and plasticity.
- Dennis Eickelbeck
- Raziye Karapinar
- Stefan Herlitze
