Nature Search

Ex-situ generation and synthetic utilization of bare trifluoromethyl anion in flow via rapid biphasic mixing

The trifluoromethyl anion rapidly decomposes into difluorocarbene (:CF₂) and fluorine ion, limiting its applicability in synthesis. Here, the authors report a strategy to generate and use the short-lived CF₃- intermediate from stable CF₃H gas via fast biphasic mixing in precisely customized flow dissolvers.

Hyune-Jea Lee
Jeong-Un Joo
Heejin Kim
ResearchOpen Access03 Mar 2023
Nature Communications

Volume: 14, P: 1-8
Integrated CO₂ capture-fixation chemistry via interfacial ionic liquid catalyst in laminar gas/liquid flow

Microfluidics is an attractive route for synthesis, but can suffer from poor reactivity with gaseous reagents. Here the authors report a microfluidic system catalysing an interfacial reaction between CO₂and liquid phase reagents by modifying silicon nanowires with immobilized ionic liquid catalysts.

Niraj K. Vishwakarma
Ajay K. Singh
Dong-Pyo Kim
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-8
Heterogeneous PdAg alloy catalyst for selective methylation of aromatic amines with formic acid under an additive-free and solvothermal one-pot condition

A heterogeneous palladium–silver alloy can catalyze selective methylation of aromatic amines under ambient pressure and without additives. Methylation of amines is used to manufacture chemicals used in fertilizers, fungicides, synthetic leathers and polymers. Formic acid, which is produced from biomass, is an environmentally friendly reagent for producing amines. They achieved complete conversion and high selectivities in the range 90–97% for methylation and dimethylation of various substituted aromatic amines only by formic acid as the source. The catalyst realized yields comparable to those of homogenous catalysts with acid additives for methylation with carbon dioxide and hydrogen under high pressure.

Ajay K Singh
Yoon-Ho Hwang
Dong-Pyo Kim
ResearchOpen Access30 Oct 2015
NPG Asia Materials

Volume: 7, P: e222
Metal-organic framework patterns and membranes with heterogeneous pores for flow-assisted switchable separations

Tailoring MOFs to allow access of complex and large molecules is a challenging task due to their inherent microporous nature. Here the authors engineer meso- and macroporous MOF patterns and membranes via a mild decarboxylation applicable to different substrates, demonstrating their potential in macromolecule separations.

Guan-Young Jeong
Ajay K. Singh
Dong-Pyo Kim
ResearchOpen Access27 Sept 2018
Nature Communications

Volume: 9, P: 1-9
Modified carbon nitride nanozyme as bifunctional glucose oxidase-peroxidase for metal-free bioinspired cascade photocatalysis

Glucose oxidase (GOx) and horseradish peroxidase (HRP) are used as an enzymatic cascade for blood glucose monitoring. Here, the authors developed a metal-free, graphitic carbon nitride-based nanozyme with GOx- and HRP-like activities and combine it with a microfluidic reactor for real-time glucose monitoring.

Peng Zhang
Dengrong Sun
Wonyong Choi
ResearchOpen Access26 Feb 2019
Nature Communications

Volume: 10, P: 1-14
One-flow syntheses of diverse heterocyclic furan chemicals directly from fructose via tandem transformation platform

We report a tandem transformation platform for one-flow syntheses of diverse heterocyclic furan chemicals.

Guan-Young Jeong
Ajay K Singh
Dong-Pyo Kim
ResearchOpen Access10 Apr 2015
NPG Asia Materials

Volume: 7, P: e173
Intensified synthesis and post-synthetic modification of covalent organic frameworks using a continuous flow of microdroplets technique

β-ketoenamine-linked covalent organic frameworks and their post-synthetic modification is performed in a continuous-flow of microdroplets in a serial manner.

Vikram Singh
Seungwook Jang
Dong-Pyo Kim
ResearchOpen Access05 Jan 2018
NPG Asia Materials

Volume: 10, P: e456
Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry

Carcinogenic compounds present difficulties in synthesis not just during reaction but perhaps especially during purification. Here, the authors report a microfluidic device for the use of carcinogenic chloromethyl methyl ether that includes a silicon nanowire separator allowing isolated, automated purification.

Ajay K. Singh
Dong-Hyeon Ko
Dong-Pyo Kim
ResearchOpen Access26 Feb 2016
Nature Communications

Volume: 7, P: 1-7
Laminated film composites of multilayered plastic film and inorganic polymer binder as an alternative to transparent and hard glass

Laminated film composite was fabricated by stacking the surface-modified poly(ethylene terephthalate) films using the initiated chemical vapor deposition (iCVD) method, with a ultraviolet (UV)-curable methacrylate-polyhedral oligomeric silsesquioxane (POSS) inorganic polymer interlayer binder to develop an alternative glass material. The 11-layered PET film/POSS composites were consolidated by UV exposure, and it increased modulus and maintained transmittance and haze.

Dong-ki Seo
Jae Bem You
Dong-Pyo Kim
Research27 Mar 2013
Polymer Journal

Volume: 45, P: 685-689
Protein-based soft micro-optics fabricated by femtosecond laser direct writing

Yun-Lu Sun
Wen-Fei Dong
Hong-Bo Sun
ResearchOpen Access17 Jan 2014
Light: Science & Applications

Volume: 3, P: e129
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis

Hyun-U Cho
Sunpil Kim
C. Justin Lee
ResearchOpen Access09 Jul 2021
Experimental & Molecular Medicine

Volume: 53, P: 1148-1158
Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening

Flow reactors have applications in reaction screening and optimisation, but typically operate in linear or radial configurations. Here a bench-top parallel flow synthesiser which distributes reagents between sixteen microreactors allows for rapid optimisation of chemical libraries, with uniform flow distribution even when clogging occurs.

Gwang-Noh Ahn
Brijesh M. Sharma
Dong-Pyo Kim
ResearchOpen Access15 Apr 2021
Communications Chemistry

Volume: 4, P: 1-8

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