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Showing 1–8 of 8 results
Advanced filters: Author: Donna G. Blackmond Clear advanced filters

  • Asymmetric autocatalysis—such as that observed experimentally in the Soai reaction—may have been responsible for the origin of biological homochirality. The magnitude of the energy imbalance required to induce directed symmetry breaking and asymmetric amplification in the Soai reaction has now been identified and compared to the parity violation energy difference.

    • Neil A. Hawbaker
    • Donna G. Blackmond
    Research
    Nature Chemistry
    Volume: 11, P: 957-962

  • The ambiphilic reactivity of alkyl sulfonyl fluorides in stereoselective cyclopropanation under Pd(II) catalysis is reported. The method provides convenient access to cis-disubstituted cyclopropanes that are otherwise challenging to access. A representative carboxylic acid cyclopropane building block is scaled up to 100 mmol, demonstrating the practicality of this transformation.

    • Yilin Cao
    • Warabhorn Rodphon
    • Keary M. Engle
    ResearchOpen Access
    Nature Synthesis
    Volume: 5, P: 281-289

  • A drawback of recently reported prebiotic routes to RNA is a requirement for enantioenriched reactants. Here, the presence of a slightly enantioenriched amino acid in the reaction mixture is shown to drive the formation of enantiopure RNA precursors. This provides a plausible scenario in which single-handed biological molecules were formed prior to the emergence of self-replicating informational polymers.

    • Jason E. Hein
    • Eric Tse
    • Donna G. Blackmond
    Research
    Nature Chemistry
    Volume: 3, P: 704-706

  • A perspective is given on how an electrocatalytic approach, inspired by decades of energy storage studies, can be used in the context of efficient cobalt-hydride generation with a variety of applications in modern organic synthesis.

    • Samer Gnaim
    • Adriano Bauer
    • Phil S. Baran
    Research
    Nature
    Volume: 605, P: 687-695

  • Droplet interface bilayer measurements have now shown that membranes formed from chiral phospholipid bilayers are enantioselectively permeable to chiral amino acids. The results show that membrane stereochemistry is necessary and sufficient to drive such enantioselective transport, presenting a new potential route to homochirality. These findings could also have implications for pharmacokinetics and drug design.

    • Juan Hu
    • Wesley G. Cochrane
    • Brian M. Paegel
    Research
    Nature Chemistry
    Volume: 13, P: 786-791