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Showing 1–8 of 8 results
Advanced filters: Author: Dorota Matelska Clear advanced filters

  • A set of three papers in Nature reports a new proteomics resource from the UK Biobank and initial analysis of common and rare genetic variant associations with plasma protein levels.

    • Ryan S. Dhindsa
    • Oliver S. Burren
    • Slavé Petrovski
    ResearchOpen Access
    Nature
    Volume: 622, P: 339-347

  • Here the authors show that expanding global ancestry diversity in genomic datasets improves detection of genomic regions intolerant to variation, identifying areas more likely to harbor disease-causing mutations.

    • Alexander L. Han
    • Chloe F. Sands
    • Ryan S. Dhindsa
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • MILTON uses phenotype information in the UK Biobank to identify clinical biomarkers and other quantitative traits that characterize diseases. It then constructs augmented cohorts by predicting undiagnosed individuals, improving power to discover gene–disease relationships.

    • Manik Garg
    • Marcin Karpinski
    • Dimitrios Vitsios
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1821-1831

  • Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP and the RNAP complex structures with two regulatory factors, RIP and TFS4 that inhibit transcription and discuss their inhibitory mechanisms.

    • Simona Pilotto
    • Thomas Fouqueau
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Transcription in archaea is known to be regulated through the recruitment of RNA polymerase to promoters. Here, the authors show that the archaeon Saccharolobus solfataricus regulates transcription globally through a rate-limiting promoter-proximal elongation step.

    • Fabian Blombach
    • Thomas Fouqueau
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Genome-wide association analysis of an improved telomere length score, calculated from quantitative PCR and whole-genome sequencing measurements in 462,666 individuals in the UK Biobank, identifies novel genes and variants underlying this trait.

    • Oliver S. Burren
    • Ryan S. Dhindsa
    • Slavé Petrovski
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1832-1840

  • Functional in vitro assays, a 1.9 Å X-ray structure and AlphaFold2 homology models reveal how the archaeal histone variant MJ1647 from Methanocaldococcus jannaschi forms a tetrameric complex capable of DNA bridging.

    • Sapir Ofer
    • Fabian Blombach
    • Finn Werner
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-16