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Showing 1–4 of 4 results
Advanced filters: Author: Doug Tischer Clear advanced filters

  • RFdiffusion2, an extension of the RFdiffusion framework, builds de novo enzyme active sites using atom-level functional group constraints.

    • Woody Ahern
    • Jason Yim
    • David Baker
    ResearchOpen Access
    Nature Methods
    Volume: 23, P: 96-105

  • A generative artificial intelligence-powered method enables de novo design of highly active enzymes based on information about the geometry of residues in the active site, without requiring protein backbone or sequence information.

    • Donghyo Kim
    • Seth M. Woodbury
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 649, P: 246-253

  • A deep-learning-based strategy is used to design artificial luciferases that catalyse the oxidative chemiluminescence of diphenylterazine with high substrate specificity and catalytic efficiency.

    • Andy Hsien-Wei Yeh
    • Christoffer Norn
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 614, P: 774-780

  • The optogenetic toolkit has rapidly expanded to include various proteins and cellular functions, such as cell signalling, that can be controlled by light. The practical considerations in using and deciding between optogenetic systems, such as systems that use light-oxygen-voltage (LOV) domains, phytochrome proteins, CRYPTOCHROME 2 (CRY2) and the fluorescent protein Dronpa, are now well defined.

    • Doug Tischer
    • Orion D. Weiner
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 551-558