Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.
- Danna Sheinboim
- Itay Maza
- Carmit Levy
