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Showing 1–2 of 2 results
Advanced filters: Author: Dughan Ahimovic Clear advanced filters

  • An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and developing more effective myeloid-targeting therapies.

    • Samarth Hegde
    • Bruno Giotti
    • Miriam Merad
    Research
    Nature
    Volume: 646, P: 1214-1222

  • The histone variant H3.3 is phosphorylated at Ser31 in induced genes, and this selective mark stimulates the histone methyltransferase SETD2 and ejects the ZMYND11 repressor, thus revealing a role for histone phosphorylation in amplifying de novo transcription.

    • Anja Armache
    • Shuang Yang
    • Steven Z. Josefowicz
    Research
    Nature
    Volume: 583, P: 852-857