Nature Search

Stable expression of the bacterial neo^r gene in Leishmania enriettii

Avraham Laban
James Finbarr Tobin
Dyann F. Wirth
Research08 Feb 1990
Nature

Volume: 343, P: 572-574
Control of tubulin gene expression in the parasitic protozoan Leishmania enriettii

Scott M. Landfear
Dyann F. Wirth
Research21 Jun 1984
Nature

Volume: 309, P: 716-717
Transformation-specific secreted phosphoproteins

Donald R. Senger
Dyann F. Wirth
Richard O. Hynes
Research07 Aug 1980
Nature

Volume: 286, P: 619-621
A broad analysis of resistance development in the malaria parasite

It is unclear whether new antimalarial compounds may rapidly lose effectiveness in the field because of parasite resistance. Here, Corey et al.investigate the acquisition of drug resistance and the extent to which common resistance mechanisms decrease susceptibility to a diverse set of 50 antimalarial compounds.

Victoria C. Corey
Amanda K. Lukens
Elizabeth A. Winzeler
ResearchOpen Access15 Jun 2016
Nature Communications

Volume: 7, P: 1-9
Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Nobutaka Kato
Eamon Comer
Stuart L. Schreiber
Amendments and Corrections28 Nov 2025
Nature

Volume: 648, P: E12-E13
In vivo screen of Plasmodium targets for mosquito-based malaria control

An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in the insect host.

Alexandra S. Probst
Douglas G. Paton
Flaminia Catteruccia
ResearchOpen Access21 May 2025
Nature

Volume: 643, P: 785-793
Harnessing genomics and genome biology to understand malaria biology

This Review describes how genome-wide analyses have provided various insights into the most lethal malarial parasite,Plasmodium falciparum, including determinants of antimalarial drug resistance. The authors also propose how genetic tools can be refined to monitor future therapeutic interventions.

Sarah K. Volkman
Daniel E. Neafsey
Dyann F. Wirth
Reviews12 Apr 2012
Nature Reviews Genetics

Volume: 13, P: 315-328
Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering

Mouhamad Sy
Awa B. Deme
Amy K. Bei
ResearchOpen Access18 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance

The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and develop high-affinity inhibitors for the enzyme, including elusive triple-site ligands.

Mark A. Tye
N. Connor Payne
Ralph Mazitschek
ResearchOpen Access25 Aug 2022
Nature Communications

Volume: 13, P: 1-17
Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique

Adeyemi T. Kayode
Fehintola V. Ajogbasile
Christian T. Happi
ResearchOpen Access12 Jan 2021
Scientific Reports

Volume: 11, P: 1-8
Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal

Senegal has initiated a national sentinel surveillance program for malaria parasite genetics. Here, the authors report data from the first year of the program and use it to investigate local malaria incidence, patterns of transmission, and genetic loci under selection.

Stephen F. Schaffner
Aida Badiane
Sarah K. Volkman
ResearchOpen Access10 Nov 2023
Nature Communications

Volume: 14, P: 1-11
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.

Selina Bopp
Charisse Flerida A. Pasaje
Dyann F. Wirth
ResearchOpen Access16 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda

Hsiao-Han Chang
Elamaran Meibalan
Matthias Marti
ResearchOpen Access20 May 2016
Scientific Reports

Volume: 6, P: 1-8
Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

Host immune responses exert selective pressure on Plasmodium falciparum. Here, the authors show that allele-specific immunity impacts the antigenic diversity of individual malaria infections. This process partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines should account for allele-specific immunity.

Angela M. Early
Marc Lievens
Daniel E. Neafsey
ResearchOpen Access11 Apr 2018
Nature Communications

Volume: 9, P: 1-10
Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Piperaquine (PPQ) resistance of Plasmodium is an increasing problem. Here, Bopp et al. find a bimodal dose−response curve of Cambodian isolates exposed to PPQ, with the area under the curve correlating with in vitro PPQ resistance, and show the importance of Plasmepsin II–III copy number to PPQ resistance.

Selina Bopp
Pamela Magistrado
Sarah K. Volkman
ResearchOpen Access02 May 2018
Nature Communications

Volume: 9, P: 1-10
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

The bicyclic azetidines, a class of potent, well-tolerated antimalarial compounds that is active against multiple stages of the Plasmodium life-cycle, has been discovered following screens against libraries of compounds reminiscent of natural products.

Nobutaka Kato
Eamon Comer
Stuart L. Schreiber
Research07 Sept 2016
Nature

Volume: 538, P: 344-349
Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression

Nutrition can affect the outcome of infectious diseases through its effects on pathogens and/or host immunity. Here, Mejia et al.show that dietary restriction protects from experimental cerebral malaria in mice through its effects on leptin and mTORC1 in T cells.

Pedro Mejia
J. Humberto Treviño-Villarreal
James R. Mitchell
Research30 Jan 2015
Nature Communications

Volume: 6, P: 1-13
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

The emergence of resistant Plasmodiumstrains fuels the search for new antimalarials. Here, the authors present a new class of potent antimalarial compounds, the triaminopyrimidines, that display low toxicity and long half-life in animal models.

Shahul Hameed P.
Suresh Solapure
Vasan K. Sambandamurthy
ResearchOpen Access31 Mar 2015
Nature Communications

Volume: 6, P: 1-11
Biological revelations

The genome of the malaria parasite was sequenced with the aim of learning more about how the parasite works, and with the hope that this would reveal potential drug targets. Has that hope been realized?

Dyann F. Wirth
News & Views03 Oct 2002
Nature

Volume: 419, P: 495-496
Malaria: A 21st century solution for an ancient disease

Dyann Wirth
News & Views01 Dec 1998
Nature Medicine

Volume: 4, P: 1360-1362
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Halofuginone was recently shown to inhibit the differentiation of T helper 17 (T_H17) cells, which are associated with autoimmune diseases. The demonstration that halofuginone inhibits prolyl-tRNA synthetase activity explains the observed activation of the amino acid response pathway in T_H17 cells and identifies amino acid restriction pathways as potential drug targets in inflammatory disease.

Tracy L Keller
Davide Zocco
Malcolm Whitman
Research12 Feb 2012
Nature Chemical Biology

Volume: 8, P: 311-317
Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity

Heterogeneity in the transmission potential of individual hosts is an important feature of malaria. Here, the authors perform a multi-regional study of the human infectious reservoir in malaria-endemic regions of Burkina Faso and Kenya.

Bronner P. Gonçalves
Melissa C. Kapulu
Teun Bousema
ResearchOpen Access26 Oct 2017
Nature Communications

Volume: 8, P: 1-11
A genome-wide map of diversity in Plasmodium falciparum

Sarah K Volkman
Pardis C Sabeti
Dyann F Wirth
Research10 Dec 2006
Nature Genetics

Volume: 39, P: 113-119
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

Karla P. Godinez-Macias
Daisy Chen
Elizabeth A. Winzeler
ResearchOpen Access04 Mar 2025
npj Drug Discovery

Volume: 2, P: 1-13
A framework for microbiome science in public health

Microbiome science is fast advancing and its careful integration into public health is detailed in this Perspective.

Jeremy E. Wilkinson
Eric A. Franzosa
Curtis Huttenhower
Reviews05 Apr 2021
Nature Medicine

Volume: 27, P: 766-774
Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting their importance in drug resistance.

Sabine Ottilie
Madeline R. Luth
Elizabeth A. Winzeler
ResearchOpen Access11 Feb 2022
Communications Biology

Volume: 5, P: 1-14
Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model

Nicanor Obaldía III
Geoffrey S. Dow
Matthias Marti
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

Martin McPhillie
Ying Zhou
Rima McLeod
ResearchOpen Access14 Jul 2016
Scientific Reports

Volume: 6, P: 1-23
Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

Martin McPhillie
Ying Zhou
Rima McLeod
Amendments and CorrectionsOpen Access23 Mar 2020
Scientific Reports

Volume: 10, P: 1-2
Salmonellae interplay with host cells

Salmonellae cause systemic diseases by invading and replicating inside epithelial cells and macrophages. Two functionally distinct type III secretion systems that are encoded onSalmonella pathogenicity islands 1 and 2 transfer Salmonellaspp. effector proteins into host cells. The dynamic molecular interplay between these bacterial effectors and host responses is discussed in this Review.

Andrea Haraga
Maikke B. Ohlson
Samuel I. Miller
Reviews01 Jan 2008
Nature Reviews Microbiology

Volume: 6, P: 53-66
LPS, TLR4 and infectious disease diversity

Samuel I. Miller
Robert K. Ernst
Martin W. Bader
Reviews01 Jan 2005
Nature Reviews Microbiology

Volume: 3, P: 36-46
Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients

Regina Joice
Charles Frantzreb
Danny A Milner Jr
Research26 Feb 2016
Modern Pathology

Volume: 29, P: 381-390

Search

Stable expression of the bacterial neo^r gene in Leishmania enriettii

Control of tubulin gene expression in the parasitic protozoan Leishmania enriettii

Transformation-specific secreted phosphoproteins

A broad analysis of resistance development in the malaria parasite

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

In vivo screen of Plasmodium targets for mosquito-based malaria control

Harnessing genomics and genome biology to understand malaria biology

Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance

Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique

Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Biological revelations

Malaria: A 21st century solution for an ancient disease

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity

A genome-wide map of diversity in Plasmodium falciparum

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

A framework for microbiome science in public health

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

Salmonellae interplay with host cells

LPS, TLR4 and infectious disease diversity

Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients

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