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Showing 1–20 of 20 results
Advanced filters: Author: Eckhard Jankowsky Clear advanced filters

  • A novel high-throughput sequencing kinetics approach is used to measure functional binding of the apparently nonspecific RNA-binding protein C5 to all possible sequence variants in its substrate binding site; C5 binds different substrate variants with affinities varying widely, and with a similar affinity distribution to that of highly specific nucleic-acid-binding proteins, but it does not bind its physiological RNA targets with the highest affinity.

    • Ulf-Peter Guenther
    • Lindsay E. Yandek
    • Eckhard Jankowsky
    Research
    Nature
    Volume: 502, P: 385-388

  • Measurement of protein binding to a large number of RNA variants reveals binding patterns and helps to quantify binding specificities, which enables the development of RNA–protein interaction models. Such models are changing the binary view of RNA binding by proteins as either specific or nonspecific.

    • Eckhard Jankowsky
    • Michael E. Harris
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 533-544

  • How do nonspecific enzymes that help to correct RNA folding identify misfolded structures among similar, properly folded RNAs? It seems that careful discrimination has little to do with it.

    • Eckhard Jankowsky
    News & Views
    Nature
    Volume: 449, P: 999-1000

  • A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.

    • Chien-Wen Chen
    • David Papadopoli
    • Maria Hatzoglou
    ResearchOpen Access
    Nature
    Volume: 641, P: 1319-1328

  • Single-molecule high-resolution optical trapping techniques elucidate the molecular mechanisms underlying the unwinding of RNA duplexes by the helicase Mtr4p, including how it restricts directional translocation to duplex regions.

    • Eric M Patrick
    • Sukanya Srinivasan
    • Matthew J Comstock
    Research
    Nature Chemical Biology
    Volume: 13, P: 99-104

  • RNA helicases of the DEAD box family are highly conserved enzymes with many roles in gene expression. Structural and mechanistic studies are uncovering the basis of their actions and have revealed roles not only in RNA unwinding but also in the remodelling of RNA–protein complexes and in the clamping of RNA to allow nucleation of larger complexes.

    • Patrick Linder
    • Eckhard Jankowsky
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 505-516

  • ATE1 is a highly specific enzyme hijacking tRNA from ribosomal pathways to install an arginine onto proteins as a post-translational modification. Here, the authors describe the structures of yeast ATE1 with or without its tRNA cofactor. ATE1 recognizes and selects tRNA in a unique mechanism.

    • Thilini Abeywansha
    • Wei Huang
    • Yi Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Dysregulated liquid-liquid phase separation (LLPS) of proteins can facilitate aberrant phase transitions and lead to protein aggregation and disease. Here, authors demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) and similar compounds are potent biphasic modulators of protein LLPS.

    • W. Michael Babinchak
    • Benjamin K. Dumm
    • Witold K. Surewicz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer progression.

    • Bartosz Mucha
    • Shuo Qie
    • J. Alan Diehl
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Time-resolved RNA–protein cross-linking with a pulsed femtosecond ultraviolet laser, followed by immunoprecipitation and high-throughput sequencing, enables the determination of binding and dissociation kinetics of the RNA-binding protein DAZL within cells.

    • Deepak Sharma
    • Leah L. Zagore
    • Eckhard Jankowsky
    Research
    Nature
    Volume: 591, P: 152-156

  • Helicase enzymes can move along DNA or RNA, unravelling the helices as they go. But simply travelling along a nucleic acid in one direction seems not to be enough for some of these molecular motors.

    • Eckhard Jankowsky
    News & Views
    Nature
    Volume: 437, P: 1245

  • All aspects of gene regulation involve RNA helicases, which bind or remodel RNA and RNA–protein complexes. Recent data establish a link between helicase structure, mechanism of function and biological roles, including in diseases such as cancer and neurological disorders, with implications for the design of small-molecule inhibitors.

    • Katherine E. Bohnsack
    • Soon Yi
    • Markus T. Bohnsack
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 749-769

  • Metagenome-wide association studies (MWAS) are designed to detect associations between the human microbiome and disease. In this Review, Jia and Wang describe the principal findings of MWAS of human diseases, and consider how these findings might be integrated into medical research and practice.

    • Jun Wang
    • Huijue Jia
    Reviews
    Nature Reviews Microbiology
    Volume: 14, P: 508-522